ZFIN ID: ZDB-GENE-021206-9
Gene Name: coagulation factor X
Gene Symbol: f10    Nomenclature History

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Previous Names: fi12c10, wu:fi12c10 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 1 Mapping Details/Browsers
Description: Predicted to have calcium ion binding activity and serine-type endopeptidase activity. Involved in hemostasis. Predicted to localize to the extracellular space. Human ortholog(s) of this gene implicated in breast cancer and factor X deficiency. Is expressed in several structures, including epidermis; liver; otic vesicle; pharyngeal arch; and yolk syncytial layer. Orthologous to human F10 (coagulation factor X).
Genome Resources: Alliance (1),  Gene:282670 (1),  Ensembl(GRCz11):ENSDARG00000088581 (2)
GENE EXPRESSION
All Expression Data: 9 figures from 3 publications
Directly Submitted Expression Data: 6 figures (8 images) from Thisse et al., 2004 [MGC:63703]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la010025Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • mi4003 Small Deletion Exon 5 Frameshift, Premature Stop TALEN
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    TALEN1-f10 1
    DISEASE ASSOCIATED WITH f10 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Factor X deficiency 227600
    DISEASE ASSOCIATED WITH f10 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process hemostasis (more)
    Cellular Component extracellular region (more)
    Molecular Function calcium ion binding (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    PTM IPR000152 EGF-type aspartate/asparagine hydroxylation site
    Domain IPR000294 Gamma-carboxyglutamic acid-rich (GLA) domain
    Domain IPR000742 EGF-like domain
    Domain IPR001254 Serine proteases, trypsin domain
    Family IPR001314 Peptidase S1A, chymotrypsin family
    Domain IPR001881 EGF-like calcium-binding domain
    Homologous_superfamily IPR009003 Peptidase S1, PA clan
    Family IPR012224 Peptidase S1A, coagulation factor VII/IX/X/C/Z
    Conserved_site IPR013032 EGF-like, conserved site
    Homologous_superfamily IPR017857 Coagulation factor-like, Gla domain superfamily
    Active_site IPR018114 Serine proteases, trypsin family, histidine active site
    Active_site IPR033116 Serine proteases, trypsin family, serine active site
    Homologous_superfamily IPR035972 Gamma-carboxyglutamic acid-rich (GLA) domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA f10-201 (1)    Ensembl 2727
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM f10 No data available
    MARKER RELATIONSHIPS
    f10 Contained in: [BAC] CH73-367P20 (1)
    [Fosmid] ZFOS-1608A7 (1), ZFOS-1962A1 (1)
    f10 Encodes: [EST] fi12c10
    [cDNA] MGC:63703 (1), MGC:113954 (1), MGC:192712 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_201462 (1) 1425 bp
    Genomic GenBank:CU929326 (1) 60413 bp
    Select Tool
    Polypeptide UniProtKB:F1QLC3 (1) 504 aa
    Sequence Clusters UniGene:150623 (1)
    Sequence Information (all 28)
    ORTHOLOGY for f10 ( Chr: 1 )
    CITATIONS (31)