Gene

f10

ID
ZDB-GENE-021206-9
Name
coagulation factor X
Symbol
f10 Nomenclature History
Previous Names
  • fi12c10
  • wu:fi12c10 (1)
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Predicted to have calcium ion binding activity and serine-type endopeptidase activity. Involved in hemostasis. Predicted to localize to extracellular space. Is expressed in several structures, including epidermis; liver; otic vesicle; pharyngeal arch; and yolk syncytial layer. Human ortholog(s) of this gene implicated in breast cancer and factor X deficiency. Orthologous to human F10 (coagulation factor X).
Genome Resources
Note
None
Expression
All Expression Data
10 figures from 4 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from Hu et al., 2017
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With f10 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Factor X deficiency 227600
Associated With f10 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR018114 Serine proteases, trypsin family, histidine active site
Active_site IPR033116 Serine proteases, trypsin family, serine active site
Domain IPR000294 Gamma-carboxyglutamic acid-rich (GLA) domain
Domain IPR000742 EGF-like domain
Domain IPR001254 Serine proteases, trypsin domain
Domain IPR001881 EGF-like calcium-binding domain
Family IPR001314 Peptidase S1A, chymotrypsin family
Family IPR012224 Peptidase S1A, coagulation factor VII/IX/X/C/Z
Homologous_superfamily IPR009003 Peptidase S1, PA clan
Homologous_superfamily IPR017857 Coagulation factor-like, Gla domain superfamily
Homologous_superfamily IPR035972 Gamma-carboxyglutamic acid-rich (GLA) domain superfamily
Homologous_superfamily IPR043504 Peptidase S1, PA clan, chymotrypsin-like fold
PTM IPR000152 EGF-type aspartate/asparagine hydroxylation site
Domain Details Per Protein
Protein Length Coagulation factor-like, Gla domain superfamily EGF-like calcium-binding domain EGF-like domain EGF-type aspartate/asparagine hydroxylation site Gamma-carboxyglutamic acid-rich (GLA) domain Gamma-carboxyglutamic acid-rich (GLA) domain superfamily Peptidase S1A, chymotrypsin family Peptidase S1A, coagulation factor VII/IX/X/C/Z Peptidase S1, PA clan Peptidase S1, PA clan, chymotrypsin-like fold Serine proteases, trypsin domain Serine proteases, trypsin family, histidine active site Serine proteases, trypsin family, serine active site
UniProtKB:Q8JHC8 474
UniProtKB:F1QLC3 504
UniProtKB:Q4V971 504
UniProtKB:Q6PGW7 504
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations