Gene

bckdk

ID
ZDB-GENE-021204-1
Name
branched chain ketoacid dehydrogenase kinase
Symbol
bckdk Nomenclature History
Previous Names
  • cb233 (1)
  • wu:fa04g07
  • wu:fb80b08
  • zgc:55984
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Predicted to enable pyruvate dehydrogenase (acetyl-transferring) kinase activity. Predicted to be involved in protein phosphorylation and regulation of glucose metabolic process. Predicted to act upstream of or within phosphorylation. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Is expressed in several structures, including midbrain neural keel; midbrain neural rod; neural plate; pancreatic system; and primary neurons. Human ortholog(s) of this gene implicated in branched-chain keto acid dehydrogenase kinase deficiency. Orthologous to human BCKDK (branched chain keto acid dehydrogenase kinase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
12 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With bckdk Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
branched-chain keto acid dehydrogenase kinase deficiency Alliance Branched-chain keto acid dehydrogenase kinase deficiency 614923
Associated With bckdk Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR003594 Histidine kinase/HSP90-like ATPase
Domain IPR004358 Signal transduction histidine kinase-related protein, C-terminal
Domain IPR005467 Histidine kinase domain
Domain IPR018955 Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal
Family IPR039028 PDK/BCKDK protein kinase
Homologous_superfamily IPR036784 Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain superfamily
Homologous_superfamily IPR036890 Histidine kinase/HSP90-like ATPase superfamily
Domain Details Per Protein
Protein Length Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain superfamily Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal Histidine kinase domain Histidine kinase/HSP90-like ATPase Histidine kinase/HSP90-like ATPase superfamily PDK/BCKDK protein kinase Signal transduction histidine kinase-related protein, C-terminal
UniProtKB:Q7ZTZ7 419
UniProtKB:B0R159 428
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations