ZFIN ID: ZDB-GENE-021115-8
Gene Name: lysyl-tRNA synthetase
Gene Symbol: kars

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Previous Names: cb530 (1), wu:fa16h02, zgc:92483

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(Including Attributions)
Location: Chr: 7 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 8 figures from 3 publications
Directly Submitted Expression Data: 6 figures (18 images) from Thisse et al., 2001 [cb530]
  1 figure (1 image) from Thisse et al., 2004 [IMAGE:7163904]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
  alar plate midbrain region, hair cell, immature eye, lens (all 19) expand
Curated Microarray Expression: GEO (1)
PHENOTYPE
Data: 2 figures from 2 publications
Observed in: eye, gut, head, heart (all 7) expand
DISEASE ASSOCIATED WITH kars HUMAN ORTHOLOG
Disease Ontology Term OMIM Term OMIM Phenotype ID
autosomal recessive nonsyndromic deafness 89 Deafness, autosomal recessive 89 613916
Charcot-Marie-Tooth disease recessive intermediate B ?Charcot-Marie-Tooth disease, recessive intermediate, B 613641
GENE ONTOLOGY
Ontology GO Term
Biological Process lysyl-tRNA aminoacylation (more)
Cellular Component cytoplasm (more)
Molecular Function ATP binding (more)
GO Terms (all 9)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR002313 (1)
  • InterPro:IPR004364 (1)
  • InterPro:IPR004365 (1)
  • InterPro:IPR006195 (1)
  • InterPro:IPR012340 (1)
  • InterPro:IPR018149 (1)
  • PROSITE:PS50862 (1)
  • Pfam:PF00152 (1)
  • Pfam:PF01336 (1)
  • EC:6.1.1.6 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA kars-001 (1) 2161
    kars-002 (1) 546
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYSNo data available
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM kars No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    karsContained in: [Fosmid] CH1073-68F2 (1) (order this)
    karsEncodes: [EST] cb530 (1) (order this), fa16h02, IMAGE:7163904 (1) (order this)
    [cDNA] MGC:92483 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001002386 (1) 2594bp
    Genomic GenBank:CU651676 (1) 35428bp
    Select Tool
    Polypeptide UniProtKB:Q6DHE6 (1) 602aa
    Sequence Clusters UniGene:75960 (1)
    Sequence Information (all 49)
    OTHER kars GENE PAGES
  • Gene:280647 (1)
  • VEGA:OTTDARG00000035398 (1)
  • Ensembl(GRCz10):ENSDARG00000103799 (1)
  • ORTHOLOGY for kars (Chr: 7)
    CITATIONS (32)