ZFIN ID: ZDB-GENE-021115-8
Gene Name: lysyl-tRNA synthetase
Gene Symbol: kars
Sequence Ontology ID : SO:0000704

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Previous Names: cb530 (1), wu:fa16h02, zgc:92483

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(Including Attributions)
Location: Chr: 7 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 8 figures from 3 publications
Directly Submitted Expression Data: 6 figures (18 images) from Thisse et al., 2001 [cb530]
  1 figure (1 image) from Thisse et al., 2004 [IMAGE:7163904]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
  alar plate midbrain region, hair cell, immature eye, lens (all 19) expand
Curated Microarray Expression: GEO (1)
PHENOTYPE
Data: 2 figures from 2 publications
Observed in: eye, gut, head, heart (all 7) expand
DISEASE ASSOCIATED WITH kars HUMAN ORTHOLOG
Disease Ontology Term OMIM Term OMIM Phenotype ID
autosomal recessive nonsyndromic deafness 89 Deafness, autosomal recessive 89 613916
Charcot-Marie-Tooth disease recessive intermediate B ?Charcot-Marie-Tooth disease, recessive intermediate, B 613641
GENE ONTOLOGY
Ontology GO Term
Biological Process lysyl-tRNA aminoacylation (more)
Cellular Component cytoplasm (more)
Molecular Function ATP binding (more)
GO Terms (all 9)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR002313 (1)
  • InterPro:IPR004364 (1)
  • InterPro:IPR004365 (1)
  • InterPro:IPR006195 (1)
  • InterPro:IPR012340 (1)
  • InterPro:IPR018149 (1)
  • InterPro:IPR034762 (1)
  • PROSITE:PS50862 (1)
  • Pfam:PF00152 (1)
  • Pfam:PF01336 (1)
  • EC:6.1.1.6 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA kars-001 (1) 2161
    kars-002 (1) 546
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM kars No data available
    MARKER RELATIONSHIPS
    karsContained in: [Fosmid] CH1073-68F2 (1) (order this)
    karsEncodes: [EST] cb530 (1) (order this), fa16h02, IMAGE:7163904 (1) (order this)
    [cDNA] MGC:92483 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001002386 (1) 2247bp
    Genomic GenBank:CU651676 (1) 35428bp
    Select Tool
    Polypeptide UniProtKB:Q6DHE6 (1) 602aa
    Sequence Clusters UniGene:75960 (1)
    Sequence Information (all 50)
    OTHER kars GENE PAGES
  • Alliance (1)
  • Gene:280647 (1)
  • VEGA:OTTDARG00000035398 (1)
  • Ensembl(GRCz10):ENSDARG00000103799 (1)
  • ORTHOLOGY for kars (Chr: 7)
    CITATIONS (34)