ZFIN ID: ZDB-GENE-021115-8
Gene Name: lysyl-tRNA synthetase 1
Gene Symbol: kars1    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: kars, cb530 (1), wu:fa16h02, zgc:92483

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Predicted to have ATP adenylyltransferase activity; lysine-tRNA ligase activity; and tRNA binding activity. Predicted to be involved in several processes, including diadenosine tetraphosphate biosynthetic process; lysyl-tRNA aminoacylation; and positive regulation of macrophage activation. Predicted to localize to several cellular components, including the aminoacyl-tRNA synthetase multienzyme complex; extracellular space; and mitochondrion. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease recessive intermediate B and autosomal recessive nonsyndromic deafness 89. Is expressed in several structures, including alar plate midbrain region; immature eye; musculature system; nervous system; and segmental plate. Orthologous to human KARS1 (lysyl-tRNA synthetase 1).
Genome Resources: Alliance (1),  Gene:280647 (1),  Ensembl(GRCz11):ENSDARG00000103799 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hi2586Tg Transgenic Insertion Intron 1 Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la011464Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa694 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15144 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21133 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21134 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-kars1
    1
    CRISPR2-kars1
    2
    PHENOTYPE
    Data: 2 figures from 2 publications
    Observed in:
    DISEASE ASSOCIATED WITH kars1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    autosomal recessive nonsyndromic deafness 89 Alliance Deafness, autosomal recessive 89 613916
    Charcot-Marie-Tooth disease recessive intermediate B Alliance ?Charcot-Marie-Tooth disease, recessive intermediate, B 613641
    DISEASE ASSOCIATED WITH kars1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process lysyl-tRNA aminoacylation (more)
    Cellular Component cytoplasm (more)
    Molecular Function aminoacyl-tRNA ligase activity (more)
    GO Terms (all 21)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Family IPR002313 Lysine-tRNA ligase, class II
    Domain IPR004364 Aminoacyl-tRNA synthetase, class II (D/K/N)
    Domain IPR004365 OB-fold nucleic acid binding domain, AA-tRNA synthetase-type
    Domain IPR006195 Aminoacyl-tRNA synthetase, class II
    Homologous_superfamily IPR012340 Nucleic acid-binding, OB-fold
    Domain IPR018149 Lysyl-tRNA synthetase, class II, C-terminal
    Family IPR034762 Bacterial/eukaryotic lysine-tRNA ligase, class II
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA kars-202 (1)    Ensembl 2161
    kars-203 (1)    Ensembl 546
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM kars1 No data available
    MARKER RELATIONSHIPS
    kars1 Contained in: [Fosmid] CH1073-68F2 (1)
    kars1 Encodes: [EST] cb530 (1) (order this), fa16h02, IMAGE:7163904 (1)
    [cDNA] MGC:92483 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001002386 (1) 2247 bp
    Genomic GenBank:CU651676 (1) 35428 bp
    Select Tool
    Polypeptide UniProtKB:Q6DHE6 (1) 602 aa
    Sequence Information (all 49)
    ORTHOLOGY for kars1 ( Chr: 7 )
    CITATIONS (41)