ZFIN ID: ZDB-GENE-021115-7
Gene Name: polo-like kinase 1 (Drosophila)
Gene Symbol: plk1    Nomenclature History

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Previous Names: plk, cb525 (1), cb636 (1), ik:tdsubc_2d1, polo-like kinase 1, wu:fb37g11, wu:fb76g03 (1), xx:tdsubc_2d1

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 1 Mapping Details/Browsers
Description: Predicted to have protein serine/threonine kinase activity. Involved in mitotic cell cycle and retina development in camera-type eye. Predicted to localize to cytoplasm; microtubule cytoskeleton; and nucleus. Is expressed in several structures, including immature eye; nervous system; neural tube; pharynx; and tail bud. Human ortholog(s) of this gene implicated in urinary bladder cancer. Orthologous to human PLK1 (polo like kinase 1).
Genome Resources: Alliance (1),  Gene:280649 (1),  Ensembl(GRCz11):ENSDARG00000058471 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hi1856Tg Transgenic Insertion Intron 1 Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la021358Tg Transgenic Insertion Unknown Unknown DNA
    sa10264 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa19428 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • tju2 Small Deletion Unknown Unknown CRISPR
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-plk1 1
    MO1-plk1 N/A 1
    MO2-plk1 N/A 1
    MO3-plk1 N/A 1
    DISEASE ASSOCIATED WITH plk1 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH plk1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process mitotic cell cycle (more)
    Cellular Component centrosome (more)
    Molecular Function ATP binding (more)
    GO Terms (all 15)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA plk1-201 (1)    Ensembl 2538
    ncRNA plk1-002 (1)    Ensembl 330
    plk1-003 (1)    Ensembl 338
    plk1-004 (1)    Ensembl 689
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM plk1 No data available
    MARKER RELATIONSHIPS
    plk1 Contained in: [BAC] CH211-14K19 (1)
    plk1 Encodes: [EST] cb525 (1) (order this), cb636 (1) (order this), fb37g11, fb76g03, tdsubc_2d1
    [STS] chunp30142
    [cDNA] MGC:110073 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001003890 (1) 2377 nt
    Genomic GenBank:BX004779 (1) 196036 nt
    Select Tool
    Polypeptide UniProtKB:Q4KMI8 (1) 595 aa
    Sequence Information (all 22)
    ORTHOLOGY for plk1 ( Chr: 1 )
    CITATIONS (46)