Gene

plk1

ID
ZDB-GENE-021115-7
Name
polo-like kinase 1 (Drosophila)
Symbol
plk1 Nomenclature History
Previous Names
  • plk
  • cb525 (1)
  • cb636 (1)
  • ik:tdsubc_2d1
  • polo-like kinase 1
  • wu:fb37g11
  • wu:fb76g03 (1)
  • xx:tdsubc_2d1
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Predicted to have protein serine/threonine kinase activity. Involved in mitotic cell cycle. Predicted to localize to cytoplasm; microtubule cytoskeleton; and nucleus. Human ortholog(s) of this gene implicated in urinary bladder cancer. Is expressed in several structures, including immature eye; nervous system; neural tube; pharynx; and tail bud. Orthologous to human PLK1 (polo like kinase 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
18 figures from 5 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
18 figures from 7 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With plk1 Human Ortholog
No data available
Associated With plk1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000719 Protein kinase domain
Domain IPR000959 POLO box domain
Domain IPR033695 Second polo-box domain
Domain IPR033701 First polo-box domain
Domain IPR033702 Polo-like kinase 1, catalytic domain
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR036947 POLO box domain superfamily
Domain Details Per Protein
Protein Length First polo-box domain POLO box domain POLO box domain superfamily Polo-like kinase 1, catalytic domain Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Second polo-box domain Serine/threonine-protein kinase, active site
UniProtKB:Q4KMI8 595
UniProtKB:Q6DRK7 595
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations