ZFIN ID: ZDB-GENE-021115-4
Gene Name: cell adhesion associated, oncogene regulated
Gene Symbol: cdon    Nomenclature History

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Previous Names: cb507 (1), wu:fa10c03, wu:fb94b11, zgc:158240

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 18 Mapping Details/Browsers
Description: Involved in negative regulation of smoothened signaling pathway. Predicted to localize to integral component of plasma membrane. Is expressed in several structures, including immature eye; mesoderm; nervous system; neural tube; and pectoral fin. Human ortholog(s) of this gene implicated in holoprosencephaly 11. Orthologous to human CDON (cell adhesion associated, oncogene regulated).
Genome Resources: Alliance (1),  Gene:280652 (1),  Ensembl(GRCz11):ENSDARG00000061328 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la020461Tg Transgenic Insertion Unknown Unknown DNA
la027963Tg Transgenic Insertion Unknown Unknown DNA
sa10351 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa23371 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa36719 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa36720 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa43164 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-cdon N/A 1
    MO2-cdon N/A 1
    MO3-cdon N/A 1
    MO4-cdon N/A 1
    MO5-cdon N/A 1
    MO6-cdon N/A 1
    MO7-cdon N/A 1
    PHENOTYPE
    Data: 2 figures from Cardozo et al., 2014
    Observed in:
    DISEASE ASSOCIATED WITH cdon HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    holoprosencephaly 11 Alliance Holoprosencephaly 11 614226
    DISEASE ASSOCIATED WITH cdon VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process negative regulation of smoothened signaling pathway (more)
    Cellular Component integral component of membrane (more)
    GO Terms (all 8)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cdon-201 (1)    Ensembl 4143
    ncRNA cdon-002 (1)    Ensembl 843
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cdon No data available
    MARKER RELATIONSHIPS
    cdon Contained in: [BAC] CH211-203F8 (1), DKEY-79N12 (1) (order this), DKEYP-68F4 (1)
    cdon Encodes: [EST] cb507 (1) (order this), fa10c03, fb94b11 (1), IMAGE:7156053 (1)
    [cDNA] cssl:d145 (1), MGC:158240 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001081628 (1) 4158 nt
    Genomic GenBank:BX005312 207484 nt Blast at MegaBLAST
    Polypeptide UniProtKB:Q1L8D0 (1) 1125 aa
    Sequence Information (all 29)
    ORTHOLOGY for cdon ( Chr: 18 )
    CITATIONS (33)