Gene
smoc2
- ID
- ZDB-GENE-021031-5
- Name
- SPARC related modular calcium binding 2
- Symbol
- smoc2 Nomenclature History
- Previous Names
-
- cb488 (1)
- wu:fb75d10
- zgc:112171
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable calcium ion binding activity. Acts upstream of or within several processes, including embryonic viscerocranium morphogenesis; myeloid cell development; and regulation of BMP signaling pathway. Predicted to be located in collagen-containing extracellular matrix and extracellular region. Is expressed in several structures, including digestive system; ectoderm; nervous system; notochord; and optic vesicle. Orthologous to human SMOC2 (SPARC related modular calcium binding 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb488 (24 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| dentin dysplasia | Alliance | Dentin dysplasia, type I, with microdontia and misshapen teeth | 125400 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR018247 | EF-Hand 1, calcium-binding site |
| Domain | IPR000716 | Thyroglobulin type-1 |
| Domain | IPR002350 | Kazal domain |
| Domain | IPR019577 | SPARC/Testican, calcium-binding domain |
| Family | IPR051950 | Developmental regulator and protease inhibitor |
| Homologous_superfamily | IPR011992 | EF-hand domain pair |
| Homologous_superfamily | IPR036857 | Thyroglobulin type-1 superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Developmental regulator and protease inhibitor | EF-Hand 1, calcium-binding site | EF-hand domain pair | Kazal domain | SPARC/Testican, calcium-binding domain | Thyroglobulin type-1 | Thyroglobulin type-1 superfamily |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0AB32T1Q2 | InterPro | 463 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available