ZFIN ID: ZDB-GENE-021030-3
Gene Name: cystathionine beta-synthase b
Gene Symbol: cbsb    Nomenclature History

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Previous Names: cbs, cb442 (1), wu:fb37g05, wu:fm61c07, wu:fq06c06, zgc:113704

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 9 Mapping Details/Browsers
Description: Predicted to have cysteine synthase activity; heme binding activity; and pyridoxal phosphate binding activity. Involved in axis elongation and regulation of homocysteine metabolic process. Predicted to localize to cytoplasm. Is expressed in several structures, including digestive system; germ ring; immature eye; musculature system; and nervous system. Human ortholog(s) of this gene implicated in coronary artery disease; homocystinuria; and neural tube defect. Orthologous to human CBS (cystathionine beta-synthase).
Genome Resources: Alliance (1),  Gene:266987 (1),  Ensembl(GRCz11):ENSDARG00000010946 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
mw207 Small Deletion Exon 4 Unknown CRISPR
sa27348 Point Mutation Unknown Premature Stop ENU
sa38725 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-cbsb 1
    MO1-cbsb N/A 2
    MO2-cbsb N/A 1
    MO3-cbsb N/A 1
    MO4-cbsb N/A 1
    DISEASE ASSOCIATED WITH cbsb HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    homocystinuria Alliance Homocystinuria, B6-responsive and nonresponsive types 236200
    Thrombosis, hyperhomocysteinemic 236200
    DISEASE ASSOCIATED WITH cbsb VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process axis elongation (more)
    Cellular Component cytoplasm (more)
    Molecular Function cystathionine beta-synthase activity (more)
    GO Terms (all 14)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cbsb-202 (1)    Ensembl 2561
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM cbsb No data available
    MARKER RELATIONSHIPS
    cbsb Contained in: [BAC] CH211-214P13 (1)
    [Fosmid] CH1073-392N17 (1)
    cbsb Encodes: [EST] cb442 (1) (order this), fb37g05, fb83h03 (1) (order this), fm61c07 (1), fq06c06 (1), IMAGE:7147404 (1)
    [cDNA] MGC:113704 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001014345 (1) 2868 nt
    Genomic GenBank:AL954142 (1) 238837 nt Blast at MegaBLAST
    Polypeptide UniProtKB:F1QIC0 (1) 597 aa
    Sequence Information (all 25)
    ORTHOLOGY for cbsb ( Chr: 9 )
    CITATIONS (34)