ZFIN is now using GRCz12tu for Genomic Data
Gene
ccnf
- ID
- ZDB-GENE-021030-2
- Name
- cyclin F
- Symbol
- ccnf Nomenclature History
- Previous Names
-
- cb443 (1)
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Predicted to be involved in several processes, including G1/S transition of mitotic cell cycle; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; and negative regulation of centrosome duplication. Predicted to act upstream of or within cell division. Predicted to be located in centriole. Predicted to be part of SCF ubiquitin ligase complex and cyclin-dependent protein kinase holoenzyme complex. Predicted to be active in cytoplasm; microtubule organizing center; and nucleus. Is expressed in several structures, including margin; nervous system; optic vesicle; tail bud; and ventral mesoderm. Orthologous to human CCNF (cyclin F).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb443 (16 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Frontotemporal dementia and/or amyotrophic lateral sclerosis 5 | 619141 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR048258 | Cyclins, cyclin-box |
| Domain | IPR001810 | F-box domain |
| Domain | IPR004367 | Cyclin, C-terminal domain |
| Domain | IPR006671 | Cyclin, N-terminal |
| Domain | IPR013763 | Cyclin-like domain |
| Family | IPR039361 | Cyclin |
| Homologous_superfamily | IPR036047 | F-box-like domain superfamily |
| Homologous_superfamily | IPR036915 | Cyclin-like superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Cyclin | Cyclin, C-terminal domain | Cyclin-like domain | Cyclin-like superfamily | Cyclin, N-terminal | Cyclins, cyclin-box | F-box domain | F-box-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q6NYX6 | InterPro | 764 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers