ZFIN ID: ZDB-GENE-021016-2
Gene Name: SEC61 translocon subunit alpha 1, like
Gene Symbol: sec61a1l    Nomenclature History

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Previous Names: cb413 (1), sec61al2, sec61b, wu:fb36f05, wu:fb36f12, wu:fb37d04, wu:fi26f11

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 6 Mapping Details/Browsers
Description: Predicted to have protein transmembrane transporter activity; ribosome binding activity; and signal sequence binding activity. Involved in pronephros development. Predicted to localize to Sec61 translocon complex. Is expressed in several structures, including EVL; anterior axial hypoblast; axis; ectoderm; and mesoderm. Human ortholog(s) of this gene implicated in familial juvenile hyperuricemic nephropathy. Orthologous to human SEC61A1 (SEC61 translocon subunit alpha 1).
Genome Resources: Alliance (1),  Gene:266796 (1),  Ensembl(GRCz11):ENSDARG00000005675 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa40769 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-sec61a1l
    1
    CRISPR2-sec61a1l
    1
    CRISPR3-sec61a1l
    2
    MO1-sec61a1l N/A 1
    PHENOTYPE
    Data: 2 figures from Bolar et al., 2016
    Observed in:
    DISEASE ASSOCIATED WITH sec61a1l HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Hyperuricemic nephropathy, familial juvenile, 4 617056
    DISEASE ASSOCIATED WITH sec61a1l VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process pronephros development (more)
    Cellular Component endoplasmic reticulum (more)
    Molecular Function protein transmembrane transporter activity (more)
    GO Terms (all 12)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA sec61a1l-201 (1)    Ensembl 2553
    ncRNA sec61a1l-002 (1)    Ensembl 687
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM sec61a1l No data available
    MARKER RELATIONSHIPS
    sec61a1l Contained in: [BAC] DKEY-178O3 (1) (order this)
    sec61a1l Contains: [SNP] rs3727996 (1)
    sec61a1l Encodes: [EST] cb413 (1) (order this), fb36f05, fb36f12, fb37d04, fb61b01 (1) (order this), fc60f11 (1) (order this), fi26f11
    [cDNA] MGC:55672 (1), MGC:192440 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_201577 (1) 2550 nt
    Genomic GenBank:BX957236 (1) 211391 nt Blast at MegaBLAST
    Polypeptide UniProtKB:A0A0J9YIG5 (1) 476 aa
    Sequence Information (all 28)
    ORTHOLOGY for sec61a1l ( Chr: 6 )
    CITATIONS (29)