ZFIN ID: ZDB-GENE-021015-1
Gene Name: glycine amidinotransferase (L-arginine:glycine amidinotransferase)
Gene Symbol: gatm    Nomenclature History

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Previous Names: agat (1), cb409 (1), wu:fa08a06

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 18 Mapping Details/Browsers
Description: Predicted to have glycine amidinotransferase activity. Predicted to be involved in creatine biosynthetic process. Predicted to localize to mitochondrion. Is expressed in several structures, including digestive system; mesoderm; musculature system; ovary; and yolk syncytial layer. Human ortholog(s) of this gene implicated in AGAT deficiency and Fanconi syndrome. Orthologous to human GATM (glycine amidinotransferase).
Genome Resources: Alliance (1),  Gene:266799 (1),  Ensembl(GRCz11):ENSDARG00000036239 (2)
Note: Added for the Thisse expression data.
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la020363Tg Transgenic Insertion Unknown Unknown DNA
sa28947 Point Mutation Unknown Splice Site ENU
sa28948 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH gatm HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    AGAT deficiency Alliance Cerebral creatine deficiency syndrome 3 612718
    Fanconi syndrome Alliance Fanconi renotubular syndrome 1 134600
    DISEASE ASSOCIATED WITH gatm VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process creatine biosynthetic process (more)
    Cellular Component membrane (more)
    Molecular Function glycine amidinotransferase activity (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    aberrant processed transcript gatm-204 (1)    Ensembl 729
    mRNA gatm-201 (1)    Ensembl 1974
    gatm-202 (1)    Ensembl 872
    gatm-205 (1)    Ensembl 829
    ncRNA gatm-005 (1)    Ensembl 856
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM gatm No data available
    MARKER RELATIONSHIPS
    gatm Contained in: [Fosmid] CH1073-396P5 (1)
    gatm Encodes: [EST] cb409 (1) (order this), fa08a06 (1)
    [cDNA] MGC:65855 (1), MGC:85735 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_199531 (1) 1722 nt
    Genomic GenBank:CU607075 (1) 16097 nt
    Polypeptide UniProtKB:F1QX52 (1) 422 aa
    Sequence Information (all 20)
    ORTHOLOGY for gatm ( Chr: 18 )
    CITATIONS (39)