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ZIRC
ZFIN ID: ZDB-GENE-020905-5
Gene Name: paired related homeobox 1a
Gene Symbol: prrx1a    Nomenclature History

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Previous Names: pmx1, prrx1, prx1 (1), cb329 (1), wu:fa09h05, wu:fb52c01, zgc:64055

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 2 Mapping Details/Browsers
Description: Predicted to have sequence-specific DNA binding activity. Involved in several processes, including atrial cardiac muscle cell action potential; epithelial to mesenchymal transition; and heart looping. Predicted to localize to the nucleus. Human ortholog(s) of this gene implicated in agnathia-otocephaly complex. Is expressed in several structures, including cranial vault; fin; gill; mesenchyme; and mesoderm. Orthologous to human PRRX1 (paired related homeobox 1).
Genome Resources: Alliance (1),  Gene:406431 (1),  Ensembl(GRCz11):ENSDARG00000033971 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
b1246 Small Deletion Unknown Frameshift, Premature Stop CRISPR
el558 Small Deletion Unknown Frameshift, Premature Stop TALEN
sa19740 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-prrx1a 1
    CRISPR2-prrx1a
    1
    CRISPR3-prrx1a
    1
    MO1-prrx1a N/A 1
    MO2-prrx1a N/A 3
    MO3-prrx1a N/A 2
    MO4-prrx1a N/A 1
    TALEN1-prrx1a 1
    DISEASE ASSOCIATED WITH prrx1a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    agnathia-otocephaly complex Alliance Agnathia-otocephaly complex 202650
    DISEASE ASSOCIATED WITH prrx1a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process atrial cardiac muscle cell action potential (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 9)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA prrx1a-201 (1)    Ensembl 1908
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM prrx1a
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(prrx1a:EGFP) prrx1a EGFP Danio rerio 2 3
    MARKER RELATIONSHIPS
    prrx1a Contained in: [BAC] DKEY-218H11 (1) (order this)
    prrx1a Encodes: [EST] cb329 (1) (order this), fa09h05 (1), fb52c01 (1)
    [cDNA] MGC:64055 (1) (order this), MGC:192275 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_214734 (1) 1617 bp
    Genomic GenBank:BX548024 (1) 218565 bp Blast at MegaBLAST
    Polypeptide UniProtKB:Q7T373 (1) 245 aa
    Sequence Clusters UniGene:32622 (1)
    Sequence Information (all 18)
    ORTHOLOGY for prrx1a ( Chr: 2 )
    CITATIONS (37)