ZFIN ID: ZDB-GENE-020905-3
Gene Name: mutS homolog 6 (E. coli)
Gene Symbol: msh6
Sequence Ontology ID : SO:0000704

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Previous Names: cb326 (1), wu:fb36c12

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(Including Attributions)
Location: Chr: 13 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Exhibits guanine/thymine mispair binding activity; predicted to contribute to ADP binding activity, MutLalpha complex binding activity, and single thymine insertion binding activity; involved in  ...
GENE EXPRESSION
All Expression Data: 10 figures from 3 publications
Directly Submitted Expression Data: 6 figures (12 images) from Thisse et al., 2001 [cb326]
Wild-type Stages, Structures: Segmentation:1-4 somites (10.33h-11.66h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
 
Curated Microarray Expression: GEO (1)
PHENOTYPE
Data: 2 figures from Feitsma et al., 2008
Observed in:
DISEASE ASSOCIATED WITH msh6 HUMAN ORTHOLOG
Disease Ontology Term OMIM Term OMIM Phenotype ID
endometrial cancer {Endometrial cancer, familial} 608089
hereditary nonpolyposis colorectal cancer type 5 Colorectal cancer, hereditary nonpolyposis, type 5 614350
Lynch syndrome Colorectal cancer, hereditary nonpolyposis, type 5 614350
Mismatch repair cancer syndrome 276300
DISEASE ASSOCIATED WITH msh6 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process maintenance of DNA repeat elements (more)
Cellular Component MutSalpha complex (more)
Molecular Function double-stranded DNA binding (more)
GO Terms (all 20)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000313 (1)
  • InterPro:IPR000432 (1)
  • InterPro:IPR007695 (1)
  • InterPro:IPR007696 (1)
  • InterPro:IPR007860 (1)
  • InterPro:IPR007861 (1)
  • InterPro:IPR015536 (1)
  • InterPro:IPR016151 (1)
  • InterPro:IPR017261 (1)
  • InterPro:IPR027417 (1)
  • InterPro:IPR036187 (1)
  • InterPro:IPR036678 (1)
  • PROSITE:PS00486 (1)
  • PROSITE:PS50812 (1)
  • Pfam:PF00488 (1)
  • Pfam:PF00855 (1)
  • Pfam:PF01624 (1)
  • Pfam:PF05188 (1)
  • Pfam:PF05190 (1)
  • Pfam:PF05192 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA msh6-001 (1) 4396
    msh6-002 (1) 444
    msh6-003 (1) 426
    msh6-004 (1) 801
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM msh6 No data available
    MARKER RELATIONSHIPS
    msh6Contained in: [Fosmid] CH1073-436F10 (1) (order this)
    msh6Contains: [SNP] rs3728599 (1)
    msh6Encodes: [EST] cb326 (1) (order this), fb36c12
    [cDNA] MGC:55252 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_182860 (1) 4385bp
    Genomic GenBank:CU468002 (1) 32834bp
    Select Tool
    Polypeptide UniProtKB:A0A0R4IAE0 (1) 1369aa
    Sequence Clusters UniGene:4108 (1)
    Sequence Information (all 21)
    OTHER msh6 GENE PAGES
  • Alliance (1)
  • Gene:260437 (1)
  • VEGA:OTTDARG00000029436 (1)
  • Ensembl(GRCz11):ENSDARG00000104541 (1)
  • ORTHOLOGY for msh6 (Chr: 13)
    CITATIONS (37)