Gene

msh6

ID
ZDB-GENE-020905-3
Name
mutS homolog 6 (E. coli)
Symbol
msh6 Nomenclature History
Previous Names
  • cb326 (1)
  • wu:fb36c12
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Exhibits guanine/thymine mispair binding activity. Predicted to contribute to MutLalpha complex binding activity; oxidized purine DNA binding activity; and single thymine insertion binding activity. Involved in maintenance of DNA repeat elements. Predicted to localize to MutSalpha complex. Is expressed in several structures, including central nervous system; immature eye; neural tube; optic primordium; and ventral mesoderm. Human ortholog(s) of this gene implicated in Lynch syndrome; colorectal carcinoma; endometrial cancer; and hereditary nonpolyposis colorectal cancer type 5. Orthologous to human MSH6 (mutS homolog 6).
Genome Resources
Note
None
Expression
All Expression Data
10 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Feitsma et al., 2008
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With msh6 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
endometrial cancer Alliance {Endometrial cancer, familial} 608089
hereditary nonpolyposis colorectal cancer type 5 Alliance Colorectal cancer, hereditary nonpolyposis, type 5 614350
Mismatch repair cancer syndrome 3 619097
Associated With msh6 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000313 PWWP domain
Domain IPR000432 DNA mismatch repair protein MutS, C-terminal
Domain IPR007695 DNA mismatch repair protein MutS-like, N-terminal
Domain IPR007696 DNA mismatch repair protein MutS, core
Domain IPR007860 DNA mismatch repair protein MutS, connector domain
Domain IPR007861 DNA mismatch repair protein MutS, clamp
Family IPR017261 DNA mismatch repair protein MutS/MSH
Family IPR042778 Zinc finger CW-type PWWP domain protein ZCWPW1/ZCWPW2
Homologous_superfamily IPR016151 DNA mismatch repair protein MutS, N-terminal
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily IPR036187 DNA mismatch repair protein MutS, core domain superfamily
Homologous_superfamily IPR036678 MutS, connector domain superfamily
Domain Details Per Protein
Protein Length DNA mismatch repair protein MutS, clamp DNA mismatch repair protein MutS, connector domain DNA mismatch repair protein MutS, core DNA mismatch repair protein MutS, core domain superfamily DNA mismatch repair protein MutS, C-terminal DNA mismatch repair protein MutS-like, N-terminal DNA mismatch repair protein MutS/MSH DNA mismatch repair protein MutS, N-terminal MutS, connector domain superfamily P-loop containing nucleoside triphosphate hydrolase PWWP domain Zinc finger CW-type PWWP domain protein ZCWPW1/ZCWPW2
UniProtKB:A0A0R4IYP8 129
UniProtKB:A0A0R4IAE0 1369
UniProtKB:Q90XA6 1369
UniProtKB:Q803S7 1369
UniProtKB:A0A0R4I9L0 234
UniProtKB:A0A0R4IFF9 109
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations