ZFIN ID: ZDB-GENE-020905-1
Gene Name: ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1
Gene Symbol: atp2a1    Nomenclature History

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Previous Names: acc, accordion, cb279 (1), serca1 (1), serca (1), wu:cegs655, wu:fb17h11, wu:fb19b10, zgc:92110

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 3 Mapping Details/Browsers
Description: Predicted to have several functions, including ATP binding activity; calcium ion binding activity; and ion transmembrane transporter activity, phosphorylative mechanism. Involved in several processes, including cellular calcium ion homeostasis; negative regulation of muscle contraction; and relaxation of skeletal muscle. Predicted to localize to several cellular components, including endoplasmic reticulum-Golgi intermediate compartment; sarcomere; and sarcoplasmic reticulum membrane. Is expressed in several structures, including eye; gill; mesoderm; musculature system; and pectoral fin. Used to study Brody myopathy. Human ortholog(s) of this gene implicated in Brody myopathy. Orthologous to human ATP2A1 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1).
Genome Resources: Alliance (1),  Gene:260440 (1),  Ensembl(GRCz11):ENSDARG00000020574 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
dta5 Point Mutation Unknown Missense ENU
mi25i Point Mutation Unknown Missense ENU
mi289a Point Mutation Unknown Missense ENU
sa10632 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa16659 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa17743 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • tc249a Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • ti284a Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tm286 Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tn218b Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tp72x Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tq206 Point Mutation Unknown Missense ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • ty20 Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-atp2a1
    2
    CRISPR2-atp2a1
    2
    MO1-atp2a1 N/A 1
    DISEASE ASSOCIATED WITH atp2a1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Brody myopathy Alliance Brody myopathy 601003
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cellular calcium ion homeostasis (more)
    Cellular Component endoplasmic reticulum-Golgi intermediate compartment (more)
    Molecular Function ATPase activity (more)
    GO Terms (all 28)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA atp2a1-201 (1)    Ensembl 3390
    atp2a1-202 (1)    Ensembl 3311
    atp2a1-203 (1)    Ensembl 1049
    atp2a1-205 (1)    Ensembl 416
    atp2a1-206 (1)    Ensembl 502
    ncRNA atp2a1-003 (1)    Ensembl 520
    atp2a1-004 (1)    Ensembl 348
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM atp2a1 No data available
    MARKER RELATIONSHIPS
    atp2a1 Contained in: [BAC] CH73-46H18 (1), CH211-11K18 (1)
    atp2a1 Contains: [SNP] rs3727695 (1), rs3727696 (1), rs3727697 (1), rs3727698 (1)
    atp2a1 Encodes: [EST] cb279 (1) (order this), cegs655 (1) (order this), fb17h11 (1), fb19b10 (1) (order this), fb39d07 (1) (order this), IMAGE:6910802 (1), IMAGE:7142105 (1)
    [cDNA] MGC:92110 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001007029 (1) 2985 nt
    Genomic GenBank:BX511232 171843 nt
    Select Tool
    Polypeptide UniProtKB:Q5U3A4 (1) 1005 aa
    Sequence Information (all 27)
    ORTHOLOGY for atp2a1 ( Chr: 3 )
    CITATIONS (56)