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ZIRC
ZFIN ID: ZDB-GENE-020731-6
Gene Name: FMRP translational regulator 1
Gene Symbol: fmr1    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 14 Mapping Details/Browsers
Description: Predicted to have mRNA 3'-UTR binding activity; protein homodimerization activity; and translation regulator activity. Involved in several processes, including nervous system development; neural crest cell fate specification; and regulation of mRNA modification. Localizes to the nucleus. Used to study autism spectrum disorder and fragile X syndrome. Human ortholog(s) of this gene implicated in fragile X syndrome; fragile X-associated tremor/ataxia syndrome; and premature ovarian failure. Is expressed in central nervous system; neurons; and testis. Orthologous to human FMR1 (FMRP translational regulator 1).
Genome Resources: Alliance (1),  Gene:259191 (1),  Ensembl(GRCz11):ENSDARG00000037433 (2)
GENE EXPRESSION
All Expression Data: 8 figures from 5 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:66179]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
fh324 Point Mutation Unknown Unknown ENU
  • China Zebrafish Resource Center (CZRC) (order this)
  • fh325 Point Mutation Unknown Unknown ENU
  • China Zebrafish Resource Center (CZRC) (order this)
  • fmr1_unrecovered Point Mutation Unknown Unknown ENU
    hu2787 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • hu2898 Point Mutation Unknown Splice Site ENU
    sa992 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa10402 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa19080 Point Mutation Unknown Splice Site ENU
    sa22461 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-fmr1 N/A 2
    MO2-fmr1 N/A 1
    DISEASE ASSOCIATED WITH fmr1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    fragile X syndrome Alliance Fragile X syndrome 300624
    fragile X-associated tremor/ataxia syndrome Alliance Fragile X tremor/ataxia syndrome 300623
    premature ovarian failure Alliance Premature ovarian failure 1 311360
    DISEASE ASSOCIATED WITH fmr1 VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    fragile X syndrome fmr1hu2787/hu2787(AB) control Kim et al., 2014
    fmr1hu2787/hu2787 standard conditions (2)
    autism spectrum disorder fmr1hu2787/hu2787(AB) control Kim et al., 2014
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process brain development (more)
    Cellular Component nucleus (more)
    Molecular Function mRNA binding (more)
    GO Terms (all 35)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA fmr1-201 (1)    Ensembl 4413
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-fmr1 polyclonal Rabbit IHC, WB 3
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM fmr1 No data available
    MARKER RELATIONSHIPS
    fmr1 Contained in: [BAC] DKEY-23L19 (1) (order this)
    fmr1 Encodes: [cDNA] MGC:66179 (1) (order this), MGC:192443 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_152963 (1) 2297 bp
    Genomic GenBank:BX005284 (1) 213404 bp Blast at MegaBLAST
    Polypeptide UniProtKB:F1R159 (1) 569 aa
    Sequence Clusters UniGene:10644 (1)
    Sequence Information (all 19)
    ORTHOLOGY for fmr1 ( Chr: 14 )
    CITATIONS (44)