Gene

thbs4b

ID

ZDB-GENE-020708-4

Name

thrombospondin 4b

Symbol

thbs4b Nomenclature History

Previous Names

thbs4 (1)
tsp4b (1)
Tsp-4a (1)
zgc:111910

Type

protein_coding_gene

Location

Chr: 21 Mapping Details/Browsers

Description

Predicted to have calcium ion binding activity and growth factor activity. Involved in tendon development. Predicted to localize to collagen-containing extracellular matrix; extracellular space; and sarcoplasmic reticulum. Is expressed in musculature system; pectoral fin; and somite. Orthologous to human THBS4 (thrombospondin 4).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

13 figures from 6 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

MGC:111910 (13 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Subramanian et al., 2014
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With thbs4b Human Ortholog

No data available

Associated With thbs4b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018097	EGF-like calcium-binding, conserved site
Domain	IPR000742	EGF-like domain
Domain	IPR001881	EGF-like calcium-binding domain
Domain	IPR008859	Thrombospondin, C-terminal
Domain	IPR024665	Thrombospondin/cartilage oligomeric matrix protein, coiled-coil domain
Domain	IPR048287	Thrombospondin-like, N-terminal domain
Homologous_superfamily	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily
Homologous_superfamily	IPR028974	TSP type-3 repeat
Homologous_superfamily	IPR046970	Thrombospondin/cartilage oligomeric matrix protein, coiled-coil domain superfamily
Repeat	IPR003367	Thrombospondin, type 3-like repeat
Repeat	IPR017897	Thrombospondin, type 3 repeat

Domain Details Per Protein

Protein	Length	Concanavalin A-like lectin/glucanase domain superfamily	EGF-like calcium-binding, conserved site	EGF-like calcium-binding domain	EGF-like domain	Thrombospondin/cartilage oligomeric matrix protein, coiled-coil domain	Thrombospondin/cartilage oligomeric matrix protein, coiled-coil domain superfamily	Thrombospondin, C-terminal	Thrombospondin-like, N-terminal domain	Thrombospondin, type 3-like repeat	Thrombospondin, type 3 repeat	TSP type-3 repeat
UniProtKB:Q8JGW0 InterPro	949

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	thbs4b-201 (1) Ensembl	Havana	3397 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	thbs4b-002 (1) Ensembl	Havana	822 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab3-thbs4b	polyclonal	thbs4b	IgG	Rabbit	IHC	GeneTex	5
Ab1-thbs4b	polyclonal	thbs4b		Rabbit	IHC		4

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations