ZFIN ID: ZDB-GENE-020530-2
Gene Name: prostaglandin-endoperoxide synthase 2a
Gene Symbol: ptgs2a    Nomenclature History

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Previous Names: Cox-2a (2), cox2 (1), ptgs2, fj02a10, unp1239, wu:fj02a10 (1), zCOX-2 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 2 Mapping Details/Browsers
Description: Exhibits peroxidase activity. Involved in animal organ development; cellular response to organic cyclic compound; and response to steroid hormone. Human ortholog(s) of this gene implicated in several diseases, including Barrett's esophagus; arthritis (multiple); cardiovascular system disease (multiple); liver disease (multiple); and lung disease (multiple). Is expressed in several structures, including cardiovascular system; digestive system; endoderm; gonad; and head. Orthologous to human PTGS2 (prostaglandin-endoperoxide synthase 2).
Genome Resources: Alliance (1),  Gene:246227 (1),  Ensembl(GRCz11):ENSDARG00000004539 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa90 Point Mutation Unknown Premature Stop ENU
sa10104 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa11800 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa16633 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa25105 Point Mutation Unknown Premature Stop ENU
    sa44528 Point Mutation Unknown Unknown ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-ptgs2a
    1
    CRISPR2-ptgs2a
    1
    MO1-ptgs2a N/A 7
    MO2-ptgs2a N/A 4
    MO3-ptgs2a N/A 1
    MO4-ptgs2a N/A 2
    MO5-ptgs2a N/A 2
    DISEASE ASSOCIATED WITH ptgs2a HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH ptgs2a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cellular response to organic cyclic compound (more)
    Molecular Function peroxidase activity (more)
    GO Terms (all 14)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR000742 EGF-like domain
    Homologous_superfamily IPR010255 Haem peroxidase superfamily
    Family IPR019791 Haem peroxidase, animal-type
    Family IPR029576 Prostaglandin G/H synthase 2
    Homologous_superfamily IPR037120 Haem peroxidase domain superfamily, animal type
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ptgs2a-201 (1)    Ensembl 2135
    ncRNA ptgs2a-002 (1)    Ensembl 673
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ptgs2a No data available
    MARKER RELATIONSHIPS
    ptgs2a Contained in: [BAC] CH73-147D18 (1)
    ptgs2a Contains: [SNP] rs3727618 (1), rs3727619 (1)
    ptgs2a Encodes: [EST] fj02a10 (1)
    [cDNA] MGC:66037 (1), MGC:77710 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_153657 (1) 2150 bp
    Genomic GenBank:CU570979 (1) 105710 bp
    Select Tool
    Polypeptide UniProtKB:Q6P4V3 (1) 601 aa
    Sequence Information (all 16)
    ORTHOLOGY for ptgs2a ( Chr: 2 )
    CITATIONS (115)