Gene

ptgs2a

ID
ZDB-GENE-020530-2
Name
prostaglandin-endoperoxide synthase 2a
Symbol
ptgs2a Nomenclature History
Previous Names
  • Cox-2a (2)
  • cox2 (1)
  • ptgs2
  • fj02a10
  • unp1239
  • wu:fj02a10 (1)
  • zCOX-2 (1)
Type
protein_coding_gene
Location
Chr: 2 Mapping Details/Browsers
Description
Exhibits peroxidase activity. Involved in animal organ development; cellular response to organic cyclic compound; and response to steroid hormone. Predicted to localize to endoplasmic reticulum membrane. Is expressed in several structures, including cardiovascular system; digestive system; endoderm; gonad; and head. Human ortholog(s) of this gene implicated in several diseases, including Barrett's esophagus; artery disease (multiple); arthritis (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human PTGS2 (prostaglandin-endoperoxide synthase 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
34 figures from 27 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
9 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ptgs2a Human Ortholog
No data available
Associated With ptgs2a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000742 EGF-like domain
Family IPR019791 Haem peroxidase, animal-type
Family IPR029576 Prostaglandin G/H synthase 2
Homologous_superfamily IPR010255 Haem peroxidase superfamily
Homologous_superfamily IPR037120 Haem peroxidase domain superfamily, animal type
Domain Details Per Protein
Protein Length EGF-like domain Haem peroxidase, animal-type Haem peroxidase domain superfamily, animal type Haem peroxidase superfamily Prostaglandin G/H synthase 2
UniProtKB:Q8JH43 601
UniProtKB:Q6P4V3 601
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations