ZFIN ID: ZDB-GENE-020530-1
Gene Name: prostaglandin-endoperoxide synthase 1
Gene Symbol: ptgs1    Nomenclature History

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Previous Names: Cox-1 (1), Cox-1b (1), cox1 (1), zCOX-1 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Exhibits peroxidase activity and prostaglandin-endoperoxide synthase activity. Involved in animal organ development; cellular response to organic cyclic compound; and vasculogenesis. Is expressed in several structures, including cardiovascular system; digestive system; eye; mesoderm; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human PTGS1 (prostaglandin-endoperoxide synthase 1).
Genome Resources: Alliance (1),  Gene:246226 (1),  Ensembl(GRCz11):ENSDARG00000052148 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la029151Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa53 Point Mutation Unknown Premature Stop ENU
    sa11791 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15398 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-ptgs1
    1
    CRISPR2-ptgs1
    1
    MO1-ptgs1 N/A 11
    MO2-ptgs1 N/A 3
    MO3-ptgs1 N/A 1
    DISEASE ASSOCIATED WITH ptgs1 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH ptgs1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cellular response to organic cyclic compound (more)
    Molecular Function peroxidase activity (more)
    GO Terms (all 15)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ptgs1-201 (1)    Ensembl 2078
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ptgs1 No data available
    MARKER RELATIONSHIPS
    ptgs1 Contained in: [BAC] CH73-24M4 (1), CH211-236K19 (1)
    ptgs1 Encodes: [cDNA] MGC:136528 (1), MGC:192858 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_153656 (1) 2094 nt
    Genomic GenBank:BX255921 (1) 142918 nt
    Select Tool
    Polypeptide UniProtKB:A0A2R8QJU6 (1) 609 aa
    Sequence Information (all 18)
    ORTHOLOGY for ptgs1 ( Chr: 5 )
    CITATIONS (72)