ZFIN ID: ZDB-GENE-020530-1
Gene Name: prostaglandin-endoperoxide synthase 1
Gene Symbol: ptgs1
Previous Names: Cox-1 (1), Cox-1b (1), cox1 (1), zCOX-1 (1)
Location: Chr: 5 Details
GENE EXPRESSION
All Expression Data: 15 figures from 11 publications
Wild-type Stages, Structures: Cleavage:16-cell (1.5h-1.75h) to Adult (90d-730d, breeding adult)
  anterior segment eye artery, blood vasculature, blood vessel endothelial cell, brain (all 31) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Mutagen Suppliers
la029151Tg Transgenic Insertion DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa53 Point Mutation ENU
    sa11791 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa15398 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • Targeting reagents: CRISPR1-ptgs1 (1), MO1-ptgs1 (2), MO2-ptgs1 (1)
    PHENOTYPE
    Data: 3 figures from 3 publications
    Observed in: brain ventricular system, brain, cilium assembly, epiboly involved in gastrulation with mouth forming second (all 16) expand
    DISEASE ASSOCIATED WITH ptgs1 HUMAN ORTHOLOGNo data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cellular response to organic cyclic compound (more)
    Molecular Function peroxidase activity (more)
    GO Terms (all 12)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000742 (1)
  • InterPro:IPR010255 (1)
  • InterPro:IPR019791 (1)
  • InterPro:IPR029580 (1)
  • PROSITE:PS50026 (1)
  • PROSITE:PS50292 (1)
  • Pfam:PF00008 (1)
  • Pfam:PF03098 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA ptgs1-001 (1) 2078
    GENE PRODUCT DESCRIPTION
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM ptgs1 No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    ptgs1Contained in: [BAC] CH73-24M4 (1) (order this), CH211-236K19 (1) (order this)
    ptgs1Encodes: [cDNA] MGC:136528 (1) (order this), MGC:192858 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_153656 (1) 2094bp
    Genomic GenBank:BX255921 (1) 142918bp
    Select Tool
    Polypeptide UniProtKB:F1R0R6 (1) 597aa
    Sequence Clusters UniGene:18294 (1)
    Sequence Information (all 17)
    OTHER ptgs1 GENE PAGES
  • Gene:246226 (1)
  • VEGA:OTTDARG00000018819 (1)
  • Ensembl(GRCz10):ENSDARG00000052148 (1)
  • ORTHOLOGY for ptgs1 (Chr: 5)
    Species Symbol Chromosome Accession # Evidence
    Human PTGS1 9
  • Gene:5742
  • OMIM:176805
  • HGNC:9604
  • Amino acid sequence comparison (3)
    Mouse Ptgs1 2
  • MGI:97797
  • Gene:19224
  • Amino acid sequence comparison (3)
    Download Curated Orthology
    CITATIONS (45)