ZFIN ID: ZDB-GENE-020530-1
Gene Name: prostaglandin-endoperoxide synthase 1
Gene Symbol: ptgs1
Previous Names: Cox-1 (1), Cox-1b (1), cox1 (1), zCOX-1 (1)
Location: Chr: 5   Details
GENE EXPRESSION
All Expression Data: 13 figures from 9 publications
Wild-type Stages, Structures: Cleavage:16-cell (1.5h-1.75h) to Adult (90d-730d, breeding adult)
  anterior segment eye artery, blood vasculature, blood vessel endothelial cell, brain (all 31) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: ptgs1sa53
Knockdown reagents: MO1-ptgs1 (2), MO2-ptgs1 (1)

Allele Type Mutagen Suppliers
la029151Tg Transgenic Insertion DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa53 Point Mutation ENU
    sa11791 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa15398 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • PHENOTYPE
    Data: 2 figures from 2 publications
    Observed in: epiboly involved in gastrulation with mouth forming second, hematopoietic stem cell, whole organism
    DISEASE ASSOCIATED WITH ptgs1 HUMAN ORTHOLOG No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cellular response to organic cyclic compound (more)
    Molecular Function peroxidase activity (more)
    GO Terms (all 12)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000742 (1)
  • InterPro:IPR010255 (1)
  • InterPro:IPR019791 (1)
  • InterPro:IPR029580 (1)
  • PROSITE:PS50026 (1)
  • PROSITE:PS50292 (1)
  • Pfam:PF03098 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA ptgs1-001 (1) 2078
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ptgs1 No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    ptgs1 Contained in: [BAC] CH73-24M4 (1) (order this), CH211-236K19 (1) (order this)
    ptgs1 Encodes: [cDNA] MGC:136528 (1) (order this), MGC:192858 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_153656 (1) 2094 bp
    Genomic GenBank:BX255921 (1) 142918 bp
    Select Tool
    Polypeptide UniProtKB:F1R0R6 (1) 597 aa
    Sequence Clusters UniGene:18294 (1)
    Sequence Information (all 17)
    OTHER ptgs1 GENE PAGES
  • Gene:246226 (1)
  • VEGA:OTTDARG00000018819 (1)
  • Ensembl(Zv9):ENSDARG00000052148 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA
    Zebrafish ptgs1 5  
    Human PTGS1 9 (9q32-q33.3)
  • OMIM:176805
  • Gene:5742
  • Mouse Ptgs1 2 ( 24.19 cM)
  • MGI:97797
  • Gene:19224
  • Orthology Details
    CITATIONS (41)