ZFIN ID: ZDB-GENE-020529-1
Gene Name: T-box transcription factor 15
Gene Symbol: tbx15    Nomenclature History

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Previous Names: zgc:158205, zgc:63576

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 9 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II activating transcription factor binding activity; and RNA polymerase II regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell fate specification; negative regulation of transcription by RNA polymerase II; and positive regulation of transcription by RNA polymerase II. Predicted to colocalize with the Tle3-Aes complex. Is expressed in several structures, including cephalic musculature; head mesenchyme; mesenchyme pectoral fin; mesoderm pectoral fin bud; and pharyngeal arch 1. Orthologous to human TBX15 (T-box transcription factor 15).
Genome Resources: Alliance (1),  Gene:246222 (1),  Ensembl(GRCz11):ENSDARG00000002582 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa41398 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH tbx15 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Cousin syndrome 260660
    DISEASE ASSOCIATED WITH tbx15 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regulation of transcription, DNA-templated (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Conserved_site IPR018186 Transcription factor, T-box, conserved site
    Family IPR001699 Transcription factor, T-box
    Homologous_superfamily IPR008967 p53-like transcription factor, DNA-binding
    Homologous_superfamily IPR036960 T-box superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA tbx15-201 (1)    Ensembl 3026
    ncRNA tbx15-002 (1)    Ensembl 2486
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM tbx15 No data available
    MARKER RELATIONSHIPS
    tbx15 Contained in: [BAC] CH211-250K6 (1)
    tbx15 Encodes: [EST] IMAGE:7147865 (1)
    [cDNA] MGC:63576 (1), MGC:158205 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_153664 (1) 3023 nt
    Genomic GenBank:BX255950 (1) 151210 nt
    Select Tool
    Polypeptide UniProtKB:B0S5M8 (1) 620 aa
    Sequence Information (all 22)
    ORTHOLOGY for tbx15 ( Chr: 9 )
    CITATIONS (26)