Gene

gpia

ID
ZDB-GENE-020513-2
Name
glucose-6-phosphate isomerase a
Symbol
gpia Nomenclature History
Previous Names
  • PGI (1)
  • pgi-1 (1)
  • pgi1 (1)
  • wu:fc02c05 (1)
  • zgc:86919
Type
protein_coding_gene
Location
Chr: 25 Mapping Details/Browsers
Description
Predicted to have glucose-6-phosphate isomerase activity and monosaccharide binding activity. Predicted to be involved in gluconeogenesis; glucose 6-phosphate metabolic process; and glycolytic process. Predicted to localize to cytosol. Is expressed in several structures, including cardiovascular system; digestive system; musculature system; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in congenital hemolytic anemia; congenital nonspherocytic hemolytic anemia; intellectual disability; and neuromuscular disease. Orthologous to human GPI (glucose-6-phosphate isomerase).
Genome Resources
Note
None
Expression
All Expression Data
21 figures from 7 publications
Cross-Species Comparison
High Throughput Data
No data available
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With gpia Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
congenital nonspherocytic hemolytic anemia Alliance Hemolytic anemia, nonspherocytic, due to glucose phosphate isomerase deficiency 613470
Associated With gpia Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018189 Phosphoglucose isomerase, conserved site
Domain IPR035476 Phosphoglucose isomerase, SIS domain 1
Domain IPR035482 Phosphoglucose isomerase, SIS domain 2
Family IPR001672 Phosphoglucose isomerase (PGI)
Homologous_superfamily IPR023096 Phosphoglucose isomerase, C-terminal
Domain Details Per Protein
Protein Length Phosphoglucose isomerase, conserved site Phosphoglucose isomerase, C-terminal Phosphoglucose isomerase (PGI) Phosphoglucose isomerase, SIS domain 1 Phosphoglucose isomerase, SIS domain 2
UniProtKB:Q5XJ09 553
UniProtKB:Q8QFU2 553
UniProtKB:F1QZL6 553
UniProtKB:Q7ZU30 553
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations