ZFIN ID: ZDB-GENE-020513-2
Gene Name: glucose-6-phosphate isomerase a
Gene Symbol: gpia    Nomenclature History

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Previous Names: PGI (1), pgi-1 (1), pgi1 (1), wu:fc02c05 (1), zgc:86919

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 25 Mapping Details/Browsers
Description: Predicted to have glucose-6-phosphate isomerase activity and monosaccharide binding activity. Predicted to be involved in gluconeogenesis; glucose 6-phosphate metabolic process; and glycolytic process. Predicted to localize to cytosol. Is expressed in several structures, including cardiovascular system; digestive system; musculature system; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in congenital hemolytic anemia; congenital nonspherocytic hemolytic anemia; intellectual disability; and neuromuscular disease. Orthologous to human GPI (glucose-6-phosphate isomerase).
Genome Resources: Alliance (1),  Gene:246094 (1),  Ensembl(GRCz11):ENSDARG00000012987 (2)
PHENOTYPE No data available
DISEASE ASSOCIATED WITH gpia HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
congenital nonspherocytic hemolytic anemia Alliance Hemolytic anemia, nonspherocytic, due to glucose phosphate isomerase deficiency 613470
DISEASE ASSOCIATED WITH gpia VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process gluconeogenesis (more)
Cellular Component cytosol (more)
Molecular Function glucose-6-phosphate isomerase activity (more)
GO Terms (all 7)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA gpia-201 (1)    Ensembl 2100
ncRNA gpia-002 (1)    Ensembl 587
gpia-003 (1)    Ensembl 320
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM gpia No data available
MARKER RELATIONSHIPS
gpia Contained in: [BAC] CH73-147D22 (1)
gpia Encodes: [EST] fc02c05 (1)
[cDNA] MGC:55667 (1), MGC:86919 (1), MGC:192852 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_144763 (1) 2075 nt
Genomic GenBank:CU181895 (1) 107064 nt
Select Tool
Polypeptide UniProtKB:F1QZL6 (1) 553 aa
Sequence Information (all 24)
ORTHOLOGY for gpia ( Chr: 25 )
CITATIONS (47)