Gene

gpia

ID
ZDB-GENE-020513-2
Name
glucose-6-phosphate isomerase a
Symbol
gpia Nomenclature History
Previous Names
  • PGI (1)
  • pgi-1 (1)
  • pgi1 (1)
  • wu:fc02c05 (1)
  • zgc:86919
Type
protein_coding_gene
Location
Chr: 25 Mapping Details/Browsers
Description
Predicted to have glucose-6-phosphate isomerase activity and monosaccharide binding activity. Predicted to be involved in gluconeogenesis; glucose 6-phosphate metabolic process; and glycolytic process. Predicted to localize to cytosol. Human ortholog(s) of this gene implicated in congenital hemolytic anemia; congenital nonspherocytic hemolytic anemia; intellectual disability; and neuromuscular disease. Is expressed in several structures, including cardiovascular system; digestive system; musculature system; nervous system; and pleuroperitoneal region. Orthologous to human GPI (glucose-6-phosphate isomerase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
22 figures from 8 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With gpia Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
congenital nonspherocytic hemolytic anemia Alliance Hemolytic anemia, nonspherocytic, due to glucose phosphate isomerase deficiency 613470
Associated With gpia Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018189 Phosphoglucose isomerase, conserved site
Domain IPR035476 Phosphoglucose isomerase, SIS domain 1
Domain IPR035482 Phosphoglucose isomerase, SIS domain 2
Family IPR001672 Phosphoglucose isomerase (PGI)
Homologous_superfamily IPR023096 Phosphoglucose isomerase, C-terminal
Homologous_superfamily IPR046348 SIS domain superfamily
Domain Details Per Protein
Protein Length Phosphoglucose isomerase, conserved site Phosphoglucose isomerase, C-terminal Phosphoglucose isomerase (PGI) Phosphoglucose isomerase, SIS domain 1 Phosphoglucose isomerase, SIS domain 2 SIS domain superfamily
UniProtKB:Q8QFU2 553
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations