Gene

igf1rb

ID
ZDB-GENE-020503-2
Name
insulin-like growth factor 1b receptor
Symbol
igf1rb Nomenclature History
Previous Names
  • IGF-IR
  • IGF-IRb (1)
  • wu:fb03h06 (1)
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process and insulin-like growth factor binding activity. Acts upstream of or within several processes, including animal organ development; fin regeneration; and insulin-like growth factor receptor signaling pathway. Predicted to be integral component of membrane. Predicted to be part of insulin receptor complex. Predicted to be active in axon. Predicted to be integral component of plasma membrane. Is expressed in several structures, including digestive system; eye; heart; musculature system; and reproductive system. Human ortholog(s) of this gene implicated in several diseases, including dementia (multiple); kidney cancer (multiple); liver disease (multiple); nervous system cancer (multiple); and neurodegenerative disease (multiple). Orthologous to human IGF1R (insulin like growth factor 1 receptor).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
17 figures from 14 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
6 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With igf1rb Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Insulin-like growth factor I, resistance to 270450
Associated With igf1rb Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008266 Tyrosine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Conserved_site IPR002011 Tyrosine-protein kinase, receptor class II, conserved site
Domain IPR000494 Receptor L-domain
Domain IPR000719 Protein kinase domain
Domain IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain IPR003961 Fibronectin type III
Domain IPR006211 Furin-like cysteine-rich domain
Domain IPR020635 Tyrosine-protein kinase, catalytic domain
Family IPR016246 Tyrosine-protein kinase, insulin-like receptor
Homologous_superfamily IPR009030 Growth factor receptor cysteine-rich domain superfamily
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR036116 Fibronectin type III superfamily
Homologous_superfamily IPR036941 Receptor L-domain superfamily
Repeat IPR006212 Furin-like repeat
Domain Details Per Protein
Protein Length Fibronectin type III Fibronectin type III superfamily Furin-like cysteine-rich domain Furin-like repeat Growth factor receptor cysteine-rich domain superfamily Immunoglobulin-like fold Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Receptor L-domain Receptor L-domain superfamily Serine-threonine/tyrosine-protein kinase, catalytic domain Tyrosine-protein kinase, active site Tyrosine-protein kinase, catalytic domain Tyrosine-protein kinase, insulin-like receptor Tyrosine-protein kinase, receptor class II, conserved site
UniProtKB:B0R0Q2 1380
UniProtKB:Q8UUY9 515
UniProtKB:A0A2R8Q206 1348
UniProtKB:Q8JID1 439
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations