ZFIN ID: ZDB-GENE-020503-2
Gene Name: insulin-like growth factor 1b receptor
Gene Symbol: igf1rb    Nomenclature History

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Previous Names: IGF-IR, IGF-IRb (1), wu:fb03h06 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Exhibits cysteine-type endopeptidase inhibitor activity involved in apoptotic process and insulin-like growth factor binding activity. Involved in several processes, including animal organ development; fin regeneration; and insulin-like growth factor receptor signaling pathway. Predicted to localize to axon and insulin receptor complex. Is expressed in several structures, including digestive system; eye; gill; heart; and reproductive system. Human ortholog(s) of this gene implicated in several diseases, including dementia (multiple); kidney cancer (multiple); liver disease (multiple); nervous system cancer (multiple); and neurodegenerative disease (multiple). Orthologous to human IGF1R (insulin like growth factor 1 receptor).
Genome Resources: Alliance (1),  Gene:245702 (1),  Ensembl(GRCz11):ENSDARG00000034434 (1)
GENE EXPRESSION
All Expression Data: 14 figures from 11 publications
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa2385 Point Mutation Unknown Premature Stop ENU
sa5760 Point Mutation Unknown Premature Stop ENU
sa11056 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa20878 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa31553 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa38598 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-igf1rb N/A 9
    MO2-igf1rb N/A 4
    DISEASE ASSOCIATED WITH igf1rb HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Insulin-like growth factor I, resistance to 270450
    DISEASE ASSOCIATED WITH igf1rb VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process insulin-like growth factor receptor signaling pathway (more)
    Cellular Component integral component of membrane (more)
    Molecular Function insulin-like growth factor binding (more)
    GO Terms (all 40)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA igf1rb-201 (1)    Ensembl 12373
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM igf1rb No data available
    MARKER RELATIONSHIPS
    igf1rb Contained in: [BAC] CH211-106J24 (1), CH211-134B16 (1)
    igf1rb Encodes: [EST] fb03h06 (1)
    [cDNA] MGC:195225 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_152969 (1) 4388 nt
    Genomic GenBank:AL928976 (1) 173937 nt
    Select Tool
    Polypeptide UniProtKB:B0R0Q2 (1) 1380 aa
    Sequence Information (all 21)
    ORTHOLOGY for igf1rb ( Chr: 7 )
    CITATIONS (80)