ZFIN ID: ZDB-GENE-020503-1
Gene Name: insulin-like growth factor 1a receptor
Gene Symbol: igf1ra
Sequence Ontology ID : SO:0000704

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: IGF-IRa (1), sb:eu1090, wu:fi20b10

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Location: Chr: 18 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 13 figures from 10 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2005 [eu1090]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
  brain, eye, gill, gonad primordium (all 11) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la020321Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la020322Tg Transgenic Insertion Unknown Unknown DNA
    sa9079 Point Mutation Unknown Splice Site ENU
    sa36639 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa36640 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa43094 Point Mutation Unknown Premature Stop ENU
    Targeting reagents: MO1-igf1ra (1), MO2-igf1ra (1)
    PHENOTYPE
    Data: 4 figures from Schlueter et al., 2006
    Observed in: anterior crista primordium, CaP motoneuron axon, cardiac ventricle, ear development (all 19) expand
    DISEASE ASSOCIATED WITH igf1ra HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    Insulin-like growth factor I, resistance to 270450
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process insulin-like growth factor receptor signaling pathway (more)
    Cellular Component integral component of membrane (more)
    Molecular Function insulin-like growth factor binding (more)
    GO Terms (all 27)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000494
  • InterPro:IPR000719
  • InterPro:IPR001245
  • InterPro:IPR002011
  • InterPro:IPR003961
  • InterPro:IPR006211
  • InterPro:IPR006212
  • InterPro:IPR008266
  • InterPro:IPR009030
  • InterPro:IPR011009
  • InterPro:IPR013783
  • InterPro:IPR016246
  • InterPro:IPR017441
  • InterPro:IPR020635
  • InterPro:IPR032675
  • PROSITE:PS00107
  • PROSITE:PS00109
  • PROSITE:PS00239
  • PROSITE:PS50011
  • PROSITE:PS50853
  • Pfam:PF00757
  • Pfam:PF01030
  • Pfam:PF07714
  • EC:2.7.10.1
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA igf1ra-001 (1) 6276
    ncRNA igf1ra-002 (1) 578
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM igf1ra
    Tg(actc1b:dnigf1ra-EGFP), Tg(hsp70l:dnigf1ra-EGFP), Tg(ins:dnigf1ra-EGFP)
    MARKER RELATIONSHIPS
    igf1raContained in: [BAC] CH211-200O3 (1) (order this), DKEY-25F3 (1) (order this)
    igf1raEncodes: [EST] eu1090 (1), fi20b10 (1)
    [cDNA] MGC:194803 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_152968 (1) 4257bp
    Genomic GenBank:BX470160 (1) 207501bp Blast at MegaBLAST
    Polypeptide UniProtKB:B3DK52 1405aa
    Sequence Clusters UniGene:104808 (1)
    Sequence Information (all 24)
    OTHER igf1ra GENE PAGES
  • Gene:245701 (1)
  • VEGA:OTTDARG00000013775 (1)
  • Ensembl(GRCz10):ENSDARG00000027423 (1)
  • ORTHOLOGY for igf1ra (Chr: 18)
    CITATIONS (66)