ZFIN ID: ZDB-GENE-020503-1
Gene Name: insulin-like growth factor 1a receptor
Gene Symbol: igf1ra    Nomenclature History

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Previous Names: IGF-IRa (1), sb:eu1090, wu:fi20b10

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 18 Mapping Details/Browsers
Description: Exhibits cysteine-type endopeptidase inhibitor activity involved in apoptotic process and insulin-like growth factor binding activity. Involved in several processes, including animal organ development; fin regeneration; and insulin-like growth factor receptor signaling pathway. Predicted to localize to axon and insulin receptor complex. Is expressed in several structures, including brain; digestive system; eye; gill; and reproductive system. Human ortholog(s) of this gene implicated in several diseases, including dementia (multiple); kidney cancer (multiple); liver disease (multiple); nervous system cancer (multiple); and neurodegenerative disease (multiple). Orthologous to human IGF1R (insulin like growth factor 1 receptor).
Genome Resources: Alliance (1),  Gene:245701 (1),  Ensembl(GRCz11):ENSDARG00000027423 (1)
GENE EXPRESSION
All Expression Data: 14 figures from 11 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2005 [eu1090]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la020321Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la020322Tg Transgenic Insertion Unknown Unknown DNA
    sa9079 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa36639 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa36640 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa43094 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-igf1ra N/A 9
    MO2-igf1ra N/A 4
    DISEASE ASSOCIATED WITH igf1ra HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Insulin-like growth factor I, resistance to 270450
    DISEASE ASSOCIATED WITH igf1ra VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process insulin-like growth factor receptor signaling pathway (more)
    Cellular Component integral component of membrane (more)
    Molecular Function insulin-like growth factor binding (more)
    GO Terms (all 40)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA igf1ra-201 (1)    Ensembl 6276
    ncRNA igf1ra-002 (1)    Ensembl 578
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM igf1ra
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(actc1b:dnigf1ra-EGFP) actc1b EGFPigf1ra Danio rerio 1 4
    Tg(hsp70l:dnigf1ra-EGFP) hsp70l EGFPigf1ra Danio rerio 1 6
    Tg(ins:dnigf1ra-EGFP) ins EGFPigf1ra Danio rerio 1 3
    MARKER RELATIONSHIPS
    igf1ra Contained in: [BAC] CH211-200O3 (1), DKEY-25F3 (1) (order this)
    igf1ra Encodes: [EST] eu1090 (1), fi20b10 (1)
    [cDNA] MGC:194803 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_152968 (1) 4257 nt
    Genomic GenBank:BX470160 (1) 207501 nt Blast at MegaBLAST
    Polypeptide UniProtKB:A0A0R4IGP2 (1) 1433 aa
    Sequence Information (all 27)
    ORTHOLOGY for igf1ra ( Chr: 18 )
    CITATIONS (96)