Gene

igf1ra

ID
ZDB-GENE-020503-1
Name
insulin-like growth factor 1a receptor
Symbol
igf1ra Nomenclature History
Previous Names
  • IGF-IRa (1)
  • sb:eu1090
  • wu:fi20b10
Type
protein_coding_gene
Location
Chr: 18 Mapping Details/Browsers
Description
Exhibits cysteine-type endopeptidase inhibitor activity involved in apoptotic process and insulin-like growth factor binding activity. Involved in several processes, including animal organ development; fin regeneration; and insulin-like growth factor receptor signaling pathway. Predicted to localize to axon and insulin receptor complex. Human ortholog(s) of this gene implicated in several diseases, including dementia (multiple); kidney cancer (multiple); liver disease (multiple); nervous system cancer (multiple); and neurodegenerative disease (multiple). Is expressed in several structures, including brain; digestive system; eye; gill; and reproductive system. Orthologous to human IGF1R (insulin like growth factor 1 receptor).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
17 figures from 14 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from Schlueter et al., 2006
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With igf1ra Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Insulin-like growth factor I, resistance to 270450
Associated With igf1ra Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008266 Tyrosine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Conserved_site IPR002011 Tyrosine-protein kinase, receptor class II, conserved site
Domain IPR000494 Receptor L-domain
Domain IPR000719 Protein kinase domain
Domain IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain IPR003961 Fibronectin type III
Domain IPR006211 Furin-like cysteine-rich domain
Domain IPR020635 Tyrosine-protein kinase, catalytic domain
Family IPR016246 Tyrosine-protein kinase, insulin-like receptor
Homologous_superfamily IPR009030 Growth factor receptor cysteine-rich domain superfamily
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR036116 Fibronectin type III superfamily
Homologous_superfamily IPR036941 Receptor L-domain superfamily
Repeat IPR006212 Furin-like repeat
Domain Details Per Protein
Protein Length Fibronectin type III Fibronectin type III superfamily Furin-like cysteine-rich domain Furin-like repeat Growth factor receptor cysteine-rich domain superfamily Immunoglobulin-like fold Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Receptor L-domain Receptor L-domain superfamily Serine-threonine/tyrosine-protein kinase, catalytic domain Tyrosine-protein kinase, active site Tyrosine-protein kinase, catalytic domain Tyrosine-protein kinase, insulin-like receptor Tyrosine-protein kinase, receptor class II, conserved site
UniProtKB:A0A0R4IGP2 1433
UniProtKB:A0A286Y9P5 1246
UniProtKB:B3DK52 1405
UniProtKB:A0A2R8QM53 1277
UniProtKB:A0A2R8QR15 1245
UniProtKB:A0A2R8Q844 1278
UniProtKB:Q1LWJ4 1405
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations