ZFIN ID: ZDB-GENE-020424-2
Gene Name: lamin B1
Gene Symbol: lmnb1    Nomenclature History

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Previous Names: fc06g01, wu:fc06g01 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 10 Mapping Details/Browsers
Description: Predicted to localize to intermediate filament. Human ortholog(s) of this gene implicated in adult-onset autosomal dominant demyelinating leukodystrophy. Orthologous to human LMNB1 (lamin B1).
Genome Resources: Alliance (1),  Gene:195816 (1),  Ensembl(GRCz11):ENSDARG00000044299 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:55459]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa38787 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH lmnb1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    adult-onset autosomal dominant demyelinating leukodystrophy Alliance Leukodystrophy, adult-onset, autosomal dominant 169500
    DISEASE ASSOCIATED WITH lmnb1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Cellular Component intermediate filament (more)
    GO Terms (all 1)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA lmnb1-202 (1)    Ensembl 3021
    lmnb1-204 (1)    Ensembl 779
    lmnb1-205 (1)    Ensembl 1037
    ncRNA lmnb1-004 (1)    Ensembl 796
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM lmnb1 No data available
    MARKER RELATIONSHIPS
    lmnb1 Contained in: [BAC] DKEY-184A18 (1) (order this)
    lmnb1 Encodes: [EST] fc06g01 (1)
    [cDNA] MGC:55459 (1), MGC:192857 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_152972 (1) 2994 nt
    Genomic GenBank:CR396586 (1) 225060 nt Blast at MegaBLAST
    Polypeptide UniProtKB:F1Q5F3 (1) 603 aa
    Sequence Information (all 26)
    ORTHOLOGY for lmnb1 ( Chr: 10 )
    CITATIONS (27)