ZFIN ID: ZDB-GENE-020419-32
Gene Name: histone deacetylase 1
Gene Symbol: hdac1    Nomenclature History

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Previous Names: hdac-1 (1), chunp6919, col, colgate, mp:zf637-2-001987, wu:fb19h11 (1), wu:fi06f03 (1), zgc:101582, zgc:65818 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 19 Mapping Details/Browsers
Description: Predicted to have histone deacetylase activity. Involved in several processes, including animal organ development; determination of dorsal identity; and nervous system development. Predicted to localize to Sin3-type complex. Is expressed in immature eye; nervous system; pectoral fin; and pharyngeal arch. Orthologous to human HDAC1 (histone deacetylase 1).
Genome Resources: Alliance (1),  Gene:192302 (1),  Ensembl(GRCz11):ENSDARG00000015427 (2)
GENE EXPRESSION
All Expression Data: 20 figures from 12 publications
Directly Submitted Expression Data: 7 figures (9 images) from Thisse et al., 2008 [MGC:101582]
  1 figure (1 image) from Thisse et al., 2004 [IMAGE:6904025]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
b382 Point Mutation Intron 4 Cryptic Acceptor Splice Site ENU
hi1618Tg Transgenic Insertion Exon 1 Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • hi2628Tg Transgenic Insertion Intron 1 Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • is70 Small Deletion Exon 5 Frameshift CRISPR
    la013452Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • nl18 Point Mutation Unknown Unknown ENU
    rw399 Point Mutation Unknown Unknown
    s436 Point Mutation Unknown Missense
    sa3005 Point Mutation Unknown Premature Stop ENU
    t22925 Point Mutation Unknown Unknown
  • European Zebrafish Resource Center (EZRC) (order this)
  • t23715 Point Mutation Unknown Unknown
  • European Zebrafish Resource Center (EZRC) (order this)
  • t24411 Point Mutation Unknown Unknown
  • European Zebrafish Resource Center (EZRC) (order this)
  • zf2150 Small Deletion Unknown Unknown CRISPR
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-hdac1 1
    CRISPR2-hdac1 2
    MO1-hdac1 N/A 20
    MO2-hdac1 N/A 1
    MO3-hdac1 N/A 1
    MO4-hdac1 N/A 1
    MO5-hdac1 N/A 2
    PHENOTYPE
    Data: 43 figures from 18 publications
    Observed in:
    DISEASE ASSOCIATED WITH hdac1 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH hdac1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process dorsal/ventral pattern formation (more)
    Cellular Component nucleus (more)
    Molecular Function histone deacetylase activity (more)
    GO Terms (all 34)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA hdac1-201 (1)    Ensembl 2242
    ncRNA hdac1-004 (1)    Ensembl 1249
    hdac1-005 (1)    Ensembl 849
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM hdac1 No data available
    MARKER RELATIONSHIPS
    hdac1 Contained in: [BAC] CH73-130A3 (1)
    hdac1 Encodes: [EST] fb19h11 (1), fi06f03 (1), IMAGE:6904025 (1), zf637-2-001987
    [STS] chunp6919
    [cDNA] MGC:65818, MGC:101582 (1), MGC:193070 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_173236 (1) 2213 nt
    Genomic GenBank:CU633192 (1) 93120 nt
    Select Tool
    Polypeptide UniProtKB:A0A2R8QIW0 (1) 484 aa
    Sequence Information (all 31)
    ORTHOLOGY for hdac1 ( Chr: 19 )
    CITATIONS (103)