ZFIN Gene: smc4

ZFIN ID: ZDB-GENE-020419-21

ZFIN ID: ZDB-GENE-020419-21

Gene Name:

structural maintenance of chromosomes 4

Gene Symbol:

smc4

Sequence Ontology ID :

SO:0000704

Previous Names:

cb788, chunp6901, fb99b10, MC4 structural maintenance of chromosomes 4-like 1, smc4l1 (1), wu:fb99b10 (1)

Location:

Chr: 15 Mapping Details/Browsers

Nomenclature History

AUTOMATED DESCRIPTION

Predicted to have ATP binding activity; predicted to be involved in chromosome organization; predicted to localize to the chromosome and nucleus; orthologous to human SMC4 (structural maintenance of ...

GENE EXPRESSION
All Expression Data:	8 figures from 2 publications
Directly Submitted Expression Data:	6 figures (8 images) from Thisse et al., 2001 [cb788]
Wild-type Stages, Structures:	Gastrula:50%-epiboly (5.25h-5.66h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
	ciliary marginal zone forebrain ventricle ventricular zone fourth ventricle gut hindbrain proliferative region hindbrain lateral line system midbrain hindbrain boundary optic cup optic tectum otic vesicle pectoral fin pectoral fin musculature pharyngeal arch 3-7 pharyngeal arch 3-7 skeleton proliferative region retina spinal cord unspecified ventricular zone
Curated Microarray Expression:	GEO (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
hi1143Tg	Transgenic Insertion	Intron 1	Unknown	DNA	Zebrafish International Resource Center (ZIRC) (order this)
sa35784	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)

PHENOTYPE

Data:	2 figures from 2 publications
Observed in:	brain central nervous system eye gut head heart liver pericardium

DISEASE ASSOCIATED WITH smc4 HUMAN ORTHOLOG No data available

DISEASE ASSOCIATED WITH smc4 VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	chromosome organization (more)
Cellular Component	chromosome (more)
Molecular Function	ATP binding (more)

GO Terms (all 4)

PROTEIN FAMILIES, DOMAINS AND SITES
InterPro:IPR003395 (1) InterPro:IPR010935 (1) InterPro:IPR024704 (1) InterPro:IPR027417 (1) InterPro:IPR036277 (1) InterPro:IPR041738 (1)	Pfam:PF02463 (1) Pfam:PF06470 (1)

TRANSCRIPTS
Type	Name	Length (bp)	Analysis
ncRNA	smc4-002 (1)	766	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	smc4-201 (1)	4193	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

GENE PRODUCT DESCRIPTION

INTERACTIONS AND PATHWAYS

ANTIBODIESNo data available

PLASMIDSNo data available

CONSTRUCTS WITH SEQUENCES FROM smc4 No data available

MARKER RELATIONSHIPS

smc4Contained in:	[BAC] CH211-196B13 (1) (order this)
smc4Encodes:	[EST] cb788 (1) (order this), fb99b10 (1) [STS] chunp6901

SEQUENCE INFORMATION

Type	Accession #	Length (bp/aa)	Analysis
RNA	RefSeq:NM_173253 (1)	4223bp	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:CR478286 (1)	188644bp	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:E7FGC2 (1)	1289aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast
Sequence Clusters	UniGene:77769 (1)

Sequence Information (all 29)

OTHER smc4 GENE PAGES

Alliance (1)

Gene:192332 (1)

VEGA:OTTDARG00000020669 (1)

Ensembl(GRCz11):ENSDARG00000038882 (2)

ORTHOLOGY for smc4 (Chr: 15)

CITATIONS (29)

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