ZFIN ID: ZDB-GENE-020419-21
Gene Name: structural maintenance of chromosomes 4
Gene Symbol: smc4

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Previous Names: cb788, chunp6901, fb99b10, MC4 structural maintenance of chromosomes 4-like 1, smc4l1 (1), wu:fb99b10 (1)

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(Including Attributions)
Location: Chr: 15 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 8 figures from 2 publications
Directly Submitted Expression Data: 6 figures (8 images) from Thisse et al., 2001 [cb788]
Wild-type Stages, Structures: Gastrula:50%-epiboly (5.25h-5.66h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
  ciliary marginal zone, forebrain ventricle ventricular zone, fourth ventricle, gut (all 20) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hi1143Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa35784 Point Mutation Unknown Premature Stop ENU
    PHENOTYPE
    Data: 2 figures from 2 publications
    Observed in: brain, central nervous system, eye, gut (all 8) expand
    DISEASE ASSOCIATED WITH smc4 HUMAN ORTHOLOGNo data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process chromosome organization (more)
    Cellular Component chromosome (more)
    Molecular Function ATP binding (more)
    GO Terms (all 4)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR003395 (1)
  • InterPro:IPR010935 (1)
  • InterPro:IPR024704 (1)
  • InterPro:IPR027417 (1)
  • Pfam:PF02463 (1)
  • Pfam:PF06470 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA smc4-001 (1) 4193
    ncRNA smc4-002 (1) 766
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYSNo data available
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM smc4 No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    smc4Contained in: [BAC] CH211-196B13 (1) (order this)
    smc4Encodes: [EST] cb788 (1) (order this), fb99b10 (1)
    [STS] chunp6901
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_173253 (1) 4213bp
    Genomic GenBank:CR478286 (1) 188644bp
    Select Tool
    Polypeptide UniProtKB:E7FGC2 (1) 1289aa
    Sequence Clusters UniGene:77769 (1)
    Sequence Information (all 29)
    OTHER smc4 GENE PAGES
  • Gene:192332 (1)
  • VEGA:OTTDARG00000020669 (1)
  • Ensembl(GRCz10):ENSDARG00000038882 (1)
  • ORTHOLOGY for smc4 (Chr: 15)
    Species Symbol Chromosome Accession # Evidence
    Human SMC4 3
  • Gene:10051
  • OMIM:605575
  • HGNC:14013
  • Amino acid sequence comparison (2)
    Conserved genome location (synteny) (2)
    Nucleotide sequence comparison (1)
    Mouse Smc4 3
  • MGI:1917349
  • Gene:70099
  • Amino acid sequence comparison (2)
    Conserved genome location (synteny) (1)
    Download Curated Orthology
    CITATIONS (23)