ZFIN ID: ZDB-GENE-020418-2
Gene Name: SEC61 translocon subunit alpha 1
Gene Symbol: sec61a1    Nomenclature History

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Previous Names: sec61a, sec61al1 (1), chunp6898, fb62c11, wu:fb62c11 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 6 Mapping Details/Browsers
Description: Predicted to have protein transmembrane transporter activity; ribosome binding activity; and signal sequence binding activity. Involved in habenula development and pronephric nephron development. Predicted to localize to Sec61 translocon complex. Is expressed in several structures, including axis; digestive system; hatching gland; midbrain hindbrain boundary; and polster. Human ortholog(s) of this gene implicated in familial juvenile hyperuricemic nephropathy. Orthologous to human SEC61A1 (SEC61 translocon subunit alpha 1).
Genome Resources: Alliance (1),  Gene:192298 (1),  Ensembl(GRCz11):ENSDARG00000021669 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
c163 Point Mutation Exon 6 Premature Stop ENU
hi1058Tg Transgenic Insertion Intron 1 Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • hi2839bTg Transgenic Insertion Intron 1 Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la011479Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa31532 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40755 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-sec61a1 N/A 2
    MO2-sec61a1 N/A 2
    DISEASE ASSOCIATED WITH sec61a1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Hyperuricemic nephropathy, familial juvenile, 4 617056
    DISEASE ASSOCIATED WITH sec61a1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process habenula development (more)
    Cellular Component endoplasmic reticulum membrane (more)
    Molecular Function protein transmembrane transporter activity (more)
    GO Terms (all 14)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA sec61a1-201 (1)    Ensembl 2586
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM sec61a1 No data available
    MARKER RELATIONSHIPS
    sec61a1 Contained in: [BAC] DKEY-197J19 (1) (order this)
    sec61a1 Encodes: [EST] fb62c11 (1) (order this), IMAGE:6907835 (1)
    [cDNA] MGC:55256 (1), MGC:76848 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_153659 (1) 2602 nt
    Genomic GenBank:CU467879 (1) 135977 nt
    Select Tool
    Polypeptide UniProtKB:Q90ZM2 (1) 476 aa
    Sequence Information (all 19)
    ORTHOLOGY for sec61a1 ( Chr: 6 )
    CITATIONS (44)