ZFIN ID: ZDB-GENE-020213-1
Gene Name: makorin, ring finger protein, 1
Gene Symbol: mkrn1    Nomenclature History

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Previous Names: fl25h08, wu:fl25h08 (1), zgc:110403

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 4 Mapping Details/Browsers
Description: Predicted to have metal ion binding activity and transferase activity. Predicted to be involved in protein ubiquitination. Human ortholog(s) of this gene implicated in gonadal disease. Is expressed in several structures, including brain; eye; gonad; integument; and liver. Orthologous to several human genes including MKRN1 (makorin ring finger protein 1).
Genome Resources: Alliance (1),  Gene:170782 (1),  Ensembl(GRCz11):ENSDARG00000041665 (2)
GENE EXPRESSION
All Expression Data: 9 figures from 2 publications
Directly Submitted Expression Data: 7 figures (8 images) from Thisse et al., 2004 [MGC:110403]
Wild-type Stages, Structures: Cleavage:2-cell (0.75h-1.0h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa45169 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH mkrn1 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH mkrn1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process protein ubiquitination (more)
    Molecular Function metal ion binding (more)
    GO Terms (all 3)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Conserved_site IPR017907 Zinc finger, RING-type, conserved site
    Domain IPR000571 Zinc finger, CCCH-type
    Domain IPR001841 Zinc finger, RING-type
    Domain IPR031644 E3 ubiquitin-protein ligase makorin 1, C-terminal
    Domain IPR041367 E3 ligase, CCCH-type zinc finger
    Homologous_superfamily IPR013083 Zinc finger, RING/FYVE/PHD-type
    Homologous_superfamily IPR036855 Zinc finger, CCCH-type superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    aberrant processed transcript mkrn1-206 (1)    Ensembl 702
    mRNA mkrn1-201 (1)    Ensembl 2383
    mkrn1-207 (1)    Ensembl 710
    ncRNA mkrn1-003 (1)    Ensembl 632
    mkrn1-004 (1)    Ensembl 814
    mkrn1-005 (1)    Ensembl 295
    mkrn1-006 (1)    Ensembl 501
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM mkrn1 No data available
    MARKER RELATIONSHIPS
    mkrn1 Contained in: [BAC] CH73-80E1 (1), CH211-9F20 (1)
    mkrn1 Encodes: [EST] fl25h08 (1)
    [cDNA] MGC:110403 (1), MGC:191911 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_152978 (1) 1583 nt
    Genomic GenBank:CR792454 (1) 195790 nt
    Select Tool
    Polypeptide UniProtKB:B2GQH3 (1) 439 aa
    Sequence Information (all 21)
    ORTHOLOGY for mkrn1 ( Chr: 4 )
    CITATIONS (22)