ZFIN ID: ZDB-GENE-020125-5
Gene Name: glutamate receptor, ionotropic, AMPA 3a
Gene Symbol: gria3a    Nomenclature History

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Previous Names: glur3a, gria3.1, zfGRIA3[a] (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Predicted to have AMPA glutamate receptor activity. Predicted to be involved in ion transport. Predicted to localize to the AMPA glutamate receptor complex. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability 94. Is expressed in nervous system. Orthologous to human GRIA3 (glutamate ionotropic receptor AMPA type subunit 3).
Genome Resources: Alliance (1),  Gene:170452 (1),  Ensembl(GRCz11):ENSDARG00000032737 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la024874Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa11259 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-gria3a
    2
    CRISPR2-gria3a
    3
    CRISPR3-gria3a
    1
    TALEN1-gria3a
    1
    TALEN2-gria3a
    1
    TALEN3-gria3a
    1
    TALEN4-gria3a
    1
    PHENOTYPE
    Data: Fig. S4 from Hwang et al., 2013
    Observed in:
    DISEASE ASSOCIATED WITH gria3a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    syndromic X-linked intellectual disability 94 Alliance Mental retardation, X-linked 94 300699
    DISEASE ASSOCIATED WITH gria3a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process ion transport (more)
    Cellular Component cell junction (more)
    Molecular Function ion channel activity (more)
    GO Terms (all 21)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR001320 Ionotropic glutamate receptor
    Family IPR001508 Ionotropic glutamate receptor, metazoa
    Domain IPR001828 Receptor, ligand binding region
    Domain IPR019594 Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
    Homologous_superfamily IPR028082 Periplasmic binding protein-like I
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA gria3a-201 (1)    Ensembl 2868
    gria3a-202 (1)    Ensembl 456
    ncRNA gria3a-003 (1)    Ensembl 757
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM gria3a No data available
    MARKER RELATIONSHIPS
    gria3a Contained in: [BAC] CH73-166N24 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_198339 (1) 2719 bp
    Genomic GenBank:CT025748 (1) 117231 bp
    Select Tool
    Polypeptide UniProtKB:A2CG69 (1) 886 aa
    Sequence Information (all 19)
    ORTHOLOGY for gria3a ( Chr: 5 )
    CITATIONS (37)