Gene

meis2a

ID

ZDB-GENE-020122-2

Name

Meis homeobox 2a

Symbol

meis2a Nomenclature History

Previous Names

meis2.2
fa26d08
wu:fa26d08 (1)

Type

protein_coding_gene

Location

Chr: 17 Mapping Details/Browsers

Description

Predicted to have DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in embryonic viscerocranium morphogenesis. Predicted to localize to nuclear chromatin. Is expressed in several structures, including anterior neural keel; hindbrain neural keel; nervous system; neural plate; and neural rod. Human ortholog(s) of this gene implicated in cleft palate, cardiac defects, and intellectual disabillity. Orthologous to human MEIS2 (Meis homeobox 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

13 figures from 7 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu315 (16 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Melvin et al., 2013
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With meis2a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
cleft palate, cardiac defects, and intellectual disabillity	Alliance	Cleft palate, cardiac defects, and impaired intellectual development	600987

Associated With meis2a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001356	Homeodomain
Domain	IPR008422	KN homeodomain
Domain	IPR032453	Homeobox protein PKNOX/Meis, N-terminal
Family	IPR050224	Three Amino acid Loop Extension (TALE) homeobox
Homologous_superfamily	IPR009057	Homedomain-like superfamily

Domain Details Per Protein

Protein	Length	Homedomain-like superfamily	Homeobox protein PKNOX/Meis, N-terminal	Homeodomain	KN homeodomain	Three Amino acid Loop Extension (TALE) homeobox
UniProtKB:A0A8M3AJB0 InterPro	402
UniProtKB:A0A8M3B2P5 InterPro	396
UniProtKB:A0A0H2UKR5 InterPro	390
UniProtKB:A0A8M3AUM6 InterPro	389
UniProtKB:A0A8M3AUL9 InterPro	408
UniProtKB:A0A8M3ARP6 InterPro	408
UniProtKB:Q6PHK8 InterPro	397
UniProtKB:A0A8M3AK57 InterPro	409

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	meis2a-201 (1) Ensembl	Ensembl	1,299 nt	Select Tool
mRNA	meis2a-202 (1) Ensembl	Ensembl	581 nt	Select Tool
mRNA	meis2a-203 (1) Ensembl	Ensembl	3,169 nt	Select Tool ZFIN BLAST
mRNA	meis2a-205 (1) Ensembl	Ensembl	1,221 nt	Select Tool ZFIN BLAST
mRNA	meis2a-206 (1) Ensembl	Ensembl	2,783 nt	Select Tool ZFIN BLAST
ncRNA	meis2a-204 (1) Ensembl	Ensembl	639 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations