Gene
meis2a
- ID
- ZDB-GENE-020122-2
- Name
- Meis homeobox 2a
- Symbol
- meis2a Nomenclature History
- Previous Names
-
- meis2.2
- fa26d08
- wu:fa26d08 (1)
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to have DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in embryonic viscerocranium morphogenesis. Predicted to localize to nuclear chromatin. Is expressed in several structures, including anterior neural keel; hindbrain neural keel; nervous system; neural plate; and neural rod. Human ortholog(s) of this gene implicated in cleft palate, cardiac defects, and intellectual disabillity. Orthologous to human MEIS2 (Meis homeobox 2).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 13 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu315 (16 images)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Melvin et al., 2013
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
cleft palate, cardiac defects, and intellectual disabillity | Alliance | Cleft palate, cardiac defects, and impaired intellectual development | 600987 |
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Length | Homedomain-like superfamily | Homeobox protein PKNOX/Meis, N-terminal | Homeodomain | KN homeodomain | Three Amino acid Loop Extension (TALE) homeobox |
---|---|---|---|---|---|---|
UniProtKB:A0A8M3AJB0
|
402 | |||||
UniProtKB:A0A8M3B2P5
|
396 | |||||
UniProtKB:A0A0H2UKR5
|
390 | |||||
UniProtKB:A0A8M3AUM6
|
389 | |||||
UniProtKB:A0A8M3AUL9
|
408 | |||||
UniProtKB:A0A8M3ARP6
|
408 | |||||
UniProtKB:Q6PHK8
|
397 | |||||
UniProtKB:A0A8M3AK57
|
409 |
Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
meis2a-201
(1)
|
Ensembl | 1,299 nt | ||
mRNA |
meis2a-202
(1)
|
Ensembl | 581 nt | ||
mRNA |
meis2a-203
(1)
|
Ensembl | 3,169 nt | ||
mRNA |
meis2a-205
(1)
|
Ensembl | 1,221 nt | ||
mRNA |
meis2a-206
(1)
|
Ensembl | 2,783 nt | ||
ncRNA |
meis2a-204
(1)
|
Ensembl | 639 nt |
Interactions and Pathways
No data available
Plasmids