ZFIN ID: ZDB-GENE-020122-2
Gene Name: Meis homeobox 2a
Gene Symbol: meis2a    Nomenclature History

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Previous Names: meis2.2, fa26d08, wu:fa26d08 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 17 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in embryonic viscerocranium morphogenesis. Predicted to localize to nucleus. Is expressed in several structures, including anterior neural keel; hindbrain neural keel; nervous system; neural plate; and neural rod. Human ortholog(s) of this gene implicated in ceft palate, cardiac defects, and intellectual disabillity. Orthologous to human MEIS2 (Meis homeobox 2).
Genome Resources: Alliance (1),  Gene:170454 (1),  Ensembl(GRCz11):ENSDARG00000098240 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-meis2a N/A 1
MO2-meis2a N/A 1
MO3-meis2a N/A 1
MO4-meis2a N/A 1
DISEASE ASSOCIATED WITH meis2a HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
cleft palate, cardiac defects, and intellectual disabillity Alliance Cleft palate, cardiac defects, and mental retardation 600987
DISEASE ASSOCIATED WITH meis2a VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process embryonic viscerocranium morphogenesis (more)
Cellular Component nucleus (more)
Molecular Function DNA binding (more)
GO Terms (all 15)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA meis2a-201 (1)    Ensembl 1299
meis2a-202 (1)    Ensembl 581
ncRNA meis2a-003 (1)    Ensembl 639
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM meis2a No data available
MARKER RELATIONSHIPS
meis2a Contained in: [Fosmid] CH1073-425J19 (1)
meis2a Encodes: [EST] eu315 (1), fa26d08 (1)
[cDNA] MGC:65757 (1), MGC:76847 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_131896 (1) 2802 nt
Genomic GenBank:CU467629 (1) 29394 nt
Select Tool
Polypeptide UniProtKB:A0A2R8QKE9 (1) 397 aa
Sequence Information (all 60)
ORTHOLOGY for meis2a ( Chr: 17 )
CITATIONS (33)