ZFIN ID: ZDB-GENE-020114-1
Gene Name: protein tyrosine kinase 2ab
Gene Symbol: ptk2ab    Nomenclature History

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Previous Names: fak1a (1), faka (1), ptk2.1, ptk2 (1), fak (1), focal adhesion kinase (1), wu:fa18c04

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 16 Mapping Details/Browsers
Description: Predicted to have ATP binding activity and protein tyrosine kinase activity. Involved in lens fiber cell morphogenesis; midbrain-hindbrain boundary morphogenesis; and protein localization. Predicted to localize to dendritic spine and focal adhesion. Is expressed in eye; notochord; segmental plate; somite; and vertical myoseptum. Human ortholog(s) of this gene implicated in leiomyoma; lung small cell carcinoma; and pulmonary hypertension. Orthologous to human PTK2 (protein tyrosine kinase 2).
Genome Resources: Alliance (1),  Gene:142986 (1),  Ensembl(GRCz11):ENSDARG00000004672 (2)
GENE EXPRESSION
All Expression Data: 8 figures from 7 publications
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
DISEASE ASSOCIATED WITH ptk2ab HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH ptk2ab VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process midbrain-hindbrain boundary morphogenesis (more)
Cellular Component cytoskeleton (more)
Molecular Function ATP binding (more)
GO Terms (all 24)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA ptk2ab-201 (1)    Ensembl 3874
ncRNA ptk2ab-002 (1)    Ensembl 845
ptk2ab-003 (1)    Ensembl 885
ptk2ab-005 (1)    Ensembl 768
ptk2ab-006 (1)    Ensembl 645
ptk2ab-008 (1)    Ensembl 537
ptk2ab-009 (1)    Ensembl 808
ptk2ab-011 (1)    Ensembl 722
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
SignaFish
ANTIBODIES
Name Type Isotype Host Organism Assay Source Publications
Ab1-ptk2 polyclonal IgG Rabbit IHC Life Technologies (Invitrogen)
9
Ab1-ptk2.1 polyclonal IgG Rabbit IHC Santa Cruz Biotechnology, Inc.
5
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM ptk2ab No data available
MARKER RELATIONSHIPS
ptk2ab Contained in: [BAC] CH211-123P18 (1), CH211-198D13 (1), DKEY-199K9 (1) (order this)
[Fosmid] CH1073-338M3 (1)
ptk2ab Encodes: [EST] fa18c04
[cDNA] MGC:66114 (1), MGC:195313 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_131796 (1) 3895 nt
Genomic GenBank:BX510336 (1) 187683 nt
Select Tool
Polypeptide UniProtKB:A0A2R8RR02 (1) 1101 aa
Sequence Information (all 65)
ORTHOLOGY for ptk2ab ( Chr: 16 )
CITATIONS (39)