ZFIN ID: ZDB-GENE-011128-9
Gene Name: guanylate cyclase 2D, retinal
Gene Symbol: gucy2d    Nomenclature History

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Previous Names: gc3 (1), GUCY2d1 (1), RETGC-3 (1), zat, zatoichi

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Predicted to have guanylate cyclase activity; natriuretic peptide receptor activity; and peptide hormone binding activity. Predicted to be involved in cGMP biosynthetic process and receptor guanylyl cyclase signaling pathway. Predicted to localize to plasma membrane. Is expressed in head. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 1; choroidal sclerosis; cone-rod dystrophy 6; congenital stationary night blindness; and retinitis pigmentosa. Orthologous to human GUCY2D (guanylate cyclase 2D, retinal).
Genome Resources: Alliance (1),  Gene:140426 (1),  Ensembl(GRCz11):ENSDARG00000026820 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
s125 Unknown Unknown Unknown ENU
s376 Unknown Unknown Unknown ENU
sa16059 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa20486 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-gucy2d N/A 1
    MO2-gucy2d N/A 1
    PHENOTYPE
    Data: 3 figures from 2 publications
    Observed in:
    DISEASE ASSOCIATED WITH gucy2d HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    choroidal sclerosis Alliance ?Choroidal dystrophy, central areolar 1 215500
    cone-rod dystrophy 6 Alliance Cone-rod dystrophy 6 601777
    Leber congenital amaurosis 1 Alliance Leber congenital amaurosis 1 204000
    Night blindness, congenital stationary, type 1I 618555
    DISEASE ASSOCIATED WITH gucy2d VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cGMP biosynthetic process (more)
    Cellular Component integral component of membrane (more)
    Molecular Function ATP binding (more)
    GO Terms (all 18)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA gucy2d-202 (1)    Ensembl 4522
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-gc3 polyclonal Rabbit IHC, WB 1
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM gucy2d No data available
    MARKER RELATIONSHIPS
    gucy2d Contained in: [BAC] CH211-284E13 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131866 (1) 3892 nt
    Genomic GenBank:BX294181 (1) 171388 nt
    Select Tool
    Polypeptide UniProtKB:A2BFQ0 (1) 1176 aa
    Sequence Information (all 20)
    ORTHOLOGY for gucy2d ( Chr: 5 )
    CITATIONS (29)