ZFIN ID: ZDB-GENE-011128-10
Gene Name: guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
Gene Symbol: gnat2    Nomenclature History

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Previous Names: GNAT3 (1), nof, Galpha t2 (1), no optokinetic response f, T alpha C (1), Tc alpha (1), transducin alpha (cone) (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 8 Mapping Details/Browsers
Description: Predicted to have G protein-coupled receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Involved in detection of light stimulus involved in visual perception. Predicted to localize to heterotrimeric G-protein complex; photoreceptor inner segment; and photoreceptor outer segment. Is expressed in pineal complex and visual system. Used to study achromatopsia and cone-rod dystrophy. Human ortholog(s) of this gene implicated in achromatopsia 4 and color blindness. Orthologous to several human genes including GNAT2 (G protein subunit alpha transducin 2).
Genome Resources: Alliance (1),  Gene:140429 (1),  Ensembl(GRCz11):ENSDARG00000042529 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
s377 Unknown Unknown Unknown ENU
sa25395 Point Mutation Unknown Premature Stop ENU
sa41206 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • w21 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • DISEASE ASSOCIATED WITH gnat2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    achromatopsia 4 Alliance Achromatopsia 4 613856
    DISEASE ASSOCIATED WITH gnat2 VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    cone-rod dystrophy gnat2w21/w21(AB) standard conditions Brockerhoff et al., 2003
    achromatopsia gnat2w21/w21(AB) standard conditions Kennedy et al., 2007
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA gnat2-201 (1)    Ensembl 2170
    gnat2-202 (1)    Ensembl 760
    ncRNA gnat2-003 (1)    Ensembl 630
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab3-gnat2 IHC 1
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM gnat2
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(-3.2gnat2:cacna2d4a-pHGFP) gnat2 cacna2d4apHGFP Danio rerio 0 4
    tg(-3.2gnat2:cacna2d4a-phgfp,myl7:egfp) gnat2myl7 cacna2d4aEGFPpHGFP Danio rerio 1 5
    Tg(-3.2gnat2:EGFP) gnat2 EGFP Danio rerio 1 18
    Tg(-3.2gnat2:GAL4-VP16,UAS:spHGFP) gnat2 GAL4spHGFPVP16 Danio rerio 1 5
    Tg(-3.2gnat2:GAP-CFP) gnat2 CFP Danio rerio 1 6
    Tg(-3.2gnat2:GCaMP3) gnat2 GCaMP Danio rerio 1 1
    Tg(-3.2gnat2:man2a1-GFP) gnat2 GFPman2a1 Danio rerio 0 1
    Tg(-3.2gnat2:man2a1-RFP) gnat2 man2a1RFP Danio rerio 0 1
    Tg(-3.5gnat2:get1-EGFP) gnat2 EGFPget1 Danio rerio 1 1
    Tg(gnat2:calr-GFP) gnat2 calrGFP Danio rerio 1 4
    Tg(gnat2:EGFP) gnat2 EGFP Danio rerio 1 1
    Tg(gnat2:GAL4-VP16-EGFP) gnat2 EGFPGAL4VP16 Danio rerio 1 2
    Tg(gnat2:GCaMP) gnat2 GCaMP Danio rerio 1 3
    Tg(gnat2:GFP-map1lc3b) gnat2 GFPmap1lc3b Danio rerio 1 6
    Tg(gnat2:GFP-rab5ab) gnat2 GFPrab5ab Danio rerio 1 3
    Tg(gnat2:GFP-rab7a) gnat2 GFPrab7a Danio rerio 1 6
    Tg(gnat2:Hsa.CETN2-EGFP) gnat2 EGFP Danio rerioHomo sapiens 1 1
    Tg(gnat2:Hsa.GUCY2D) gnat2 Danio rerioHomo sapiens 1 3
    Tg(gnat2:Hsa.GUCY2D_E837D_R838S) gnat2 Danio rerioHomo sapiens 1 3
    Tg(gnat2:kif17-GFP) gnat2 GFPkif17 Danio rerio 1 4
    tg(gnat2:kif17_s815a-gfp) gnat2 GFPkif17 Danio rerio 1 1
    tg(gnat2:kif17_s815d-gfp) gnat2 GFPkif17 Danio rerio 1 1
    Tg(gnat2:LIFEACT-GFP) gnat2 GFPLIFEACT Danio rerio 1 1
    Tg(gnat2:MA-YFP-2A-thrb) gnat2 thrbYFP Danio rerio 1 3
    Tg(gnat2:man2a1-RFP) gnat2 man2a1RFP Danio rerio 1 1
    Tg(gnat2:mCherry-2xMmu.Mcoln1) gnat2 mCherry Danio rerioMus musculus 1 1
    Tg(gnat2:mCherry-CAAX) gnat2 CAAXmCherry Danio rerio 1 1
    Tg(gnat2:mCherry-GFP-map1lc3b) gnat2 GFPmap1lc3bmCherry Danio rerio 1 1
    Tg(gnat2:mCherry-rab8a) gnat2 mCherryrab8a Danio rerio 1 1
    Tg(gnat2:MITO-cpYFP) gnat2 cpYFPMITO Danio rerio 1 2
    Tg(gnat2:MITO-GCaMP3) gnat2 GCaMPMITO Danio rerio 1 2
    Tg(gnat2:Mmu.Arl13b-mCherry) gnat2 mCherry Danio rerioMus musculus 1 3
    Tg(gnat2:NTR-EGFP) gnat2 EGFPNTR Danio rerio 1 2
    Tg(gnat2:sypb-CFP) gnat2 CFPsypb Danio rerio 1 4
    Tg(gnat2:TagRFP-FYVE) gnat2 FYVETagRFP Danio rerio 1 2
    Tg(gnat2:tdEos-Dme.Atub84b) gnat2 tdEos Danio rerioDrosophila melanogaster 1 1
    Tg(gnat2:YFP-FYVE) gnat2 FYVEYFP Danio rerio 1 1
    Tg1(gnat2:EGFP) gnat2 EGFP Danio rerio 1 1
    MARKER RELATIONSHIPS
    gnat2 Contained in: [BAC] CH211-77C7 (1)
    gnat2 Encodes: [cDNA] MGC:73135 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131869 (1) 2126 nt
    Genomic GenBank:CU462975 (1) 148505 nt
    Select Tool
    Polypeptide UniProtKB:Q90WX5 (1) 354 aa
    Sequence Information (all 12)
    ORTHOLOGY for gnat2 ( Chr: 8 )
    CITATIONS (95)