Gene

gnat2

ID
ZDB-GENE-011128-10
Name
guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
Symbol
gnat2 Nomenclature History
Previous Names
  • GNAT3 (1)
  • nof
  • Galpha t2 (1)
  • no optokinetic response f
  • T alpha C (1)
  • Tc alpha (1)
  • transducin alpha (cone) (1)
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Predicted to have G protein-coupled receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Involved in detection of light stimulus involved in visual perception. Predicted to localize to heterotrimeric G-protein complex; photoreceptor inner segment; and photoreceptor outer segment. Is expressed in pineal complex and visual system. Used to study achromatopsia and cone-rod dystrophy. Human ortholog(s) of this gene implicated in achromatopsia 4 and color blindness. Orthologous to several human genes including GNAT2 (G protein subunit alpha transducin 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
39 figures from 27 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Phenotype Annotation (1994-2006)
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With gnat2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
achromatopsia 4 Alliance Achromatopsia 4 613856
Associated With gnat2 Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit
Family IPR001408 G-protein alpha subunit, group I
Homologous_superfamily IPR011025 G protein alpha subunit, helical insertion
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Domain Details Per Protein
Protein Length G-protein alpha subunit, group I G protein alpha subunit, helical insertion Guanine nucleotide binding protein (G-protein), alpha subunit P-loop containing nucleoside triphosphate hydrolase
UniProtKB:Q90WX5 354
UniProtKB:B8JL40 179
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab3-gnat2
  • IHC
1
Ab1-gnat2 polyclonal Rabbit
  • IHC
  • WB
2
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations