ZFIN ID: ZDB-GENE-011128-10
Gene Name: guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
Gene Symbol: gnat2

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Previous Names: GNAT3 (1), nof, Galpha t2 (1), no optokinetic response f, T alpha C (1), Tc alpha (1), transducin alpha (cone) (1)

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(Including Attributions)
Location: Chr: 8 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 25 figures from 17 publications
Wild-type Stages, Structures: Pharyngula:Prim-5 (24.0h-30.0h) to Adult (90d-730d, breeding adult)
  epiphysis, eye, photoreceptor outer segment layer retinal cone cell, pineal complex (all 13) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
s377 Unknown Unknown Unknown ENU
sa25395 Point Mutation Unknown Premature Stop ENU
sa41206 Point Mutation Unknown Splice Site ENU
w21 Point Mutation Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE
    Data: 2 figures from Phenotype Annotation (1994-2006)
    Observed in: eye, melanocyte, pigment cell, sensory system (all 6) expand
    DISEASE ASSOCIATED WITH gnat2 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    achromatopsia 4 Achromatopsia-4 613856
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process detection of light stimulus involved in visual perception (more)
    Cellular Component heterotrimeric G-protein complex (more)
    Molecular Function G-protein beta/gamma-subunit complex binding (more)
    GO Terms (all 15)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001019 (1)
  • InterPro:IPR001408 (1)
  • InterPro:IPR011025 (1)
  • InterPro:IPR027417 (1)
  • Pfam:PF00503 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA gnat2-001 (1) 2170
    gnat2-002 (1) 760
    ncRNA gnat2-003 (1) 630
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYSNo data available
    ANTIBODIES
    Ab3-gnat2 (1)
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM gnat2
    Tg(-3.2gnat2:cacna2d4a-pHGFP), Tg(-3.2gnat2:EGFP), Tg(-3.2gnat2:GAL4-VP16,UAS:spHGFP), Tg(-3.2gnat2:GAP-CFP), Tg(-3.2gnat2:man2a1-GFP) (all 23) expand
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    gnat2Contained in: [BAC] CH211-77C7 (1) (order this)
    gnat2Encodes: [cDNA] MGC:73135 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131869 (1) 2126bp
    Genomic GenBank:CU462975 (1) 148505bp
    Select Tool
    Polypeptide UniProtKB:Q90WX5 (1) 354aa
    Sequence Clusters UniGene:81958 (1)
    Sequence Information (all 12)
    OTHER gnat2 GENE PAGES
  • Gene:140429 (1)
  • VEGA:OTTDARG00000028798 (1)
  • Ensembl(GRCz10):ENSDARG00000042529 (1)
  • ORTHOLOGY for gnat2 (Chr: 8)
    Species Symbol Chromosome Accession # Evidence
    Human GNAT2 1
  • Gene:2780
  • OMIM:139340
  • HGNC:4394
  • Amino acid sequence comparison (1)
    Conserved genome location (synteny) (1)
    Mouse Gnat2 3
  • MGI:95779
  • Gene:14686
  • Amino acid sequence comparison (1)
    Conserved genome location (synteny) (1)
    Download Curated Orthology
    CITATIONS (69)