Gene

gnat2

ID
ZDB-GENE-011128-10
Name
guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
Symbol
gnat2 Nomenclature History
Previous Names
  • GNAT3 (1)
  • nof
  • Galpha t2 (1)
  • no optokinetic response f
  • T alpha C (1)
  • Tc alpha (1)
  • transducin alpha (cone) (1)
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Predicted to have G protein-coupled receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Involved in detection of light stimulus involved in visual perception. Predicted to localize to heterotrimeric G-protein complex; photoreceptor inner segment; and photoreceptor outer segment. Is expressed in pineal complex and visual system. Used to study achromatopsia and cone-rod dystrophy. Human ortholog(s) of this gene implicated in achromatopsia 4 and color blindness. Orthologous to several human genes including GNAT2 (G protein subunit alpha transducin 2).
Genome Resources
Note
None
Expression
All Expression Data
37 figures from 25 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Phenotype Annotation (1994-2006)
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With gnat2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
achromatopsia 4 Alliance Achromatopsia 4 613856
Associated With gnat2 Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit
Family IPR001408 G-protein alpha subunit, group I
Homologous_superfamily IPR011025 G protein alpha subunit, helical insertion
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Domain Details Per Protein
Protein Length G-protein alpha subunit, group I G protein alpha subunit, helical insertion Guanine nucleotide binding protein (G-protein), alpha subunit P-loop containing nucleoside triphosphate hydrolase
UniProtKB:B8JL40 179
UniProtKB:Q90WX5 354
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab3-gnat2
  • IHC
1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations