Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-011128-10
Gene Name: guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
Gene Symbol: gnat2
Previous Names: GNAT3 (1), nof, Galpha t2 (1), no optokinetic response f, T alpha C (1), Tc alpha (1), transducin alpha (cone) (1)
Location: Chr: 8   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 19 figures from 14 publications
Wild-type Stages, Structures: Hatching:Long-pec (48.0h-60.0h) to Adult (90d-730d, breeding adult)
  eye, retina, retinal cone cell, retinal cone cell photoreceptor outer segment (all 6) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: 5 genotypes
Alleles: s377, w21
PHENOTYPE
Data: 2 figures from Phenotype Annotation (1994-2006)
Observed in: eye, melanocyte, pigment cell, sensory system (all 6) expand

Phenotype of Human Orthologue OMIM Phenotype ID
Achromatopsia-4 613856
GENE ONTOLOGY
Ontology GO Term
Biological Process detection of light stimulus involved in visual perception (more)
Cellular Component heterotrimeric G-protein complex (more)
Molecular Function G-protein beta/gamma-subunit complex binding (more)
GO Terms (all 17)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001019 (1)
  • InterPro:IPR001408 (1)
  • InterPro:IPR011025 (1)
  • InterPro:IPR027417 (1)
  • Pfam:PF00503 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA gnat2-001 (1) 2170
    gnat2-002 (1) 760
    ncRNA gnat2-003 (1) 630
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM gnat2
    Tg(-3.2gnat2:cacna2d4a-pHGFP), Tg(-3.2gnat2:EGFP), Tg(-3.2gnat2:GAL4-VP16,UAS:SpHGFP), Tg(-3.2gnat2:GAP-CFP), Tg(-3.2gnat2:man2a1-GFP) (all 18) expand
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    gnat2 Contained in: [BAC] CH211-77C7 (1) (order this)
    gnat2 Encodes: [cDNA] MGC:73135 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131869 (1) 2126 bp
    Genomic GenBank:CU462975 (1) 148505 bp
    Select Tool
    Polypeptide UniProtKB:Q90WX5 (1) 354 aa
    Sequence Clusters UniGene:81958 (1)
    Sequence Information (all 12)
    OTHER gnat2 GENE PAGES
  • Gene:140429 (1)
  • VEGA:OTTDARG00000028798 (1)
  • Ensembl(Zv9):ENSDARG00000042529 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish gnat2 8  
    Human GNAT2 1 (1p13.1)
  • OMIM:139340
  • Gene:2780
  • Mouse Gnat2 3 ( 46.83 cM)
  • MGI:95779
  • Gene:14686
  • Orthology Details
    CITATIONS (60)