ZFIN ID: ZDB-GENE-011109-2
Gene Name: Kruppel-like factor 2b
Gene Symbol: klf2b    Nomenclature History

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Previous Names: cb125 (1), sb:cb125, zgc:91780

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Ambiguous Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in negative regulation of mesodermal cell fate specification; regulation of ectodermal cell fate specification; and ventricular compact myocardium morphogenesis. Predicted to localize to the nucleus. Is expressed in several structures, including EVL; ectoderm; pectoral fin; presumptive ectoderm; and trunk vasculature. Orthologous to human KLF2 (Kruppel like factor 2).
Genome Resources: Alliance (1),  Gene:117509 (1),  Ensembl(GRCz11):ENSDARG00000040432 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
bns12 Small Deletion Unknown Unknown TALEN
ihb249 Indel Exon 2 Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • ihb250 Indel Exon 2 Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • sa43252 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa45666 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-klf2b 1
    MO1-klf2b N/A 1
    MO2-klf2b N/A 2
    MO3-klf2b N/A 1
    TALEN1-klf2b 1
    DISEASE ASSOCIATED WITH klf2b HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH klf2b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process negative regulation of mesodermal cell fate specification (more)
    Cellular Component nucleus (more)
    Molecular Function metal ion binding (more)
    GO Terms (all 8)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR013087 Zinc finger C2H2-type
    Homologous_superfamily IPR036236 Zinc finger C2H2 superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA klf2b-001 (1) 3626
    Browsers: NCBI
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM klf2b
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(fli1:klf2b-2A-tdTomato) fli1 2Aklf2bTomato Danio rerio 1 1
    Tg(hsp70l:klf2b,EGFP) hsp70l EGFPklf2b Danio rerio 3 3
    tg(myl7:klf2b-2a-tdtomato) myl7 2Aklf2bTomato Danio rerio 1 1
    MARKER RELATIONSHIPS
    klf2b Contained in: [BAC] CH73-309D6 (1)
    klf2b Encodes: [EST] cb125 (1) (order this)
    [cDNA] MGC:91780 (1), MGC:192950 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131857 (1) 3573 nt
    Genomic GenBank:CU693373 (1) 79762 nt
    Select Tool
    Polypeptide UniProtKB:Q90XE7 (1) 363 aa
    Sequence Information (all 17)
    ORTHOLOGY for klf2b ( Ambiguous )
    CITATIONS (36)