ZFIN ID: ZDB-GENE-011010-3
Gene Name: aldehyde dehydrogenase 1 family, member A2
Gene Symbol: aldh1a2    Nomenclature History

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Previous Names: raldh2 (1), neckless, nls, no-fin (1), nof (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Predicted to have aldehyde dehydrogenase (NAD+) activity. Involved in several processes, including animal organ development; face morphogenesis; and myelination. Is expressed in several structures, including head; heart; immature eye; mesoderm; and pleuroperitoneal region. Orthologous to human ALDH1A2 (aldehyde dehydrogenase 1 family member A2).
Genome Resources: Alliance (1),  Gene:116713 (1),  Ensembl(GRCz11):ENSDARG00000053493 (1)
GENE EXPRESSION
All Expression Data: 118 figures from 89 publications
Wild-type Stages, Structures: Blastula:1k-cell (3.0h-3.33h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
i26 Point Mutation Unknown Missense ENU
nju26Tg Transgenic Insertion Unknown Unknown DNA_AND_CRISPR
nju27Tg Transgenic Insertion Unknown Unknown DNA_AND_CRISPR
nz15 Point Mutation Unknown Premature Stop ENU
sa2367 Point Mutation Unknown Splice Site ENU
sa16776 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • tpl137 Small Deletion Exon 8 Exon Loss of Exon 8 CRISPR
    tpl138 Small Deletion Exon 8 Exon Loss of Exon 8 CRISPR
    tpl139Tg Transgenic Insertion Intron 7 Unknown DNA_AND_CRISPR
    tpl140Tg Transgenic Insertion Unknown Unknown DNA_AND_CRISPR
    u11 Point Mutation Unknown Missense ENU
    um22 Point Mutation Unknown Missense ENU
    PHENOTYPE
    Data: 38 figures from 22 publications
    Observed in:
    DISEASE ASSOCIATED WITH aldh1a2 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH aldh1a2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process pronephric duct morphogenesis (more)
    Molecular Function oxidoreductase activity (more)
    GO Terms (all 28)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA aldh1a2-201 (1)    Ensembl 3252
    ncRNA aldh1a2-002 (1)    Ensembl 699
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-aldh1a2 polyclonal IgG Rabbit IHC GeneTex
    10
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM aldh1a2
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg1BAC(aldh1a2:aldh1a2-GFP) aldh1a2 aldh1a2GFP Danio rerio 1 6
    TgBAC(2aldh1a2:aldh1a2-GFP) aldh1a2 aldh1a2GFP Danio rerio 1 2
    MARKER RELATIONSHIPS
    aldh1a2 Contained in: [BAC] CH211-94N14 (1)
    aldh1a2 Contains: [SNP] rs3727470 (1)
    aldh1a2 Encodes: [EST] fb50h01
    [cDNA] MGC:195324 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131850 (1) 2244 nt
    Genomic GenBank:CR392043 (1) 112955 nt
    Select Tool
    Polypeptide UniProtKB:B3DKM0 (1) 518 aa
    Sequence Information (all 21)
    ORTHOLOGY for aldh1a2 ( Chr: 7 )
    CITATIONS (235)