ZFIN ID: ZDB-GENE-010906-2
Gene Name: endothelin receptor type Aa
Gene Symbol: ednraa    Nomenclature History

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Previous Names: Ednra2 (1), ednra, etID40953.1 (1), parade (1), pde, wu:fb75g12

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 1 Mapping Details/Browsers
Description: Predicted to have endothelin receptor activity. Involved in cartilage development; developmental pigmentation; and regulation of proton transport. Predicted to localize to integral component of membrane. Is expressed in epithelium; gill; neural crest; pharyngeal arch; and vasculature. Human ortholog(s) of this gene implicated in hypertension (multiple); lung disease; mandibulofacial dysostosis with alopecia; migraine; and obstructive sleep apnea. Orthologous to human EDNRA (endothelin receptor type A).
Genome Resources: Alliance (1),  Gene:114550 (1),  Ensembl(GRCz11):ENSDARG00000011876 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hu4140 Point Mutation Exon 5 Premature Stop ENU
sa1973 Point Mutation Unknown Premature Stop ENU
sa11317 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa13839 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa19531 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa19532 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa32714 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • tj262 Unknown Unknown Exon Loss of Exon 7, Frameshift ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tv212 Unknown Unknown Exon Loss of Exon 6, Frameshift ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO2-ednraa N/A 3
    MO3-ednraa N/A 1
    MO4-ednraa N/A 1
    DISEASE ASSOCIATED WITH ednraa HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    mandibulofacial dysostosis with alopecia Alliance Mandibulofacial dysostosis with alopecia 616367
    migraine Alliance {Migraine, resistance to} 157300
    DISEASE ASSOCIATED WITH ednraa VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cartilage development (more)
    Cellular Component integral component of membrane (more)
    Molecular Function endothelin receptor activity (more)
    GO Terms (all 12)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ednraa-201 (1)    Ensembl 2665
    ednraa-203 (1)    Ensembl 200
    ncRNA ednraa-003 (1)    Ensembl 391
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ednraa No data available
    MARKER RELATIONSHIPS
    ednraa Contained in: [BAC] CH211-172J10 (1)
    ednraa Encodes: [EST] fb75g12
    [cDNA] MGC:172066 (1), MGC:193800 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001099445 (1) 1658 nt
    Genomic GenBank:CR762429 (1) 150566 nt
    Select Tool
    Polypeptide UniProtKB:A5JV23 (1) 422 aa
    Sequence Information (all 34)
    ORTHOLOGY for ednraa ( Chr: 1 )
    CITATIONS (40)