Gene
etv6
- ID
- ZDB-GENE-010727-1
- Name
- ETS variant transcription factor 6
- Symbol
- etv6 Nomenclature History
- Previous Names
-
- id:ibd2308
- ztel (1)
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Acts upstream of or within embryonic hemopoiesis. Predicted to be active in nucleus. Is expressed in several structures, including brain; germ ring; intermediate cell mass of mesoderm; mesoderm; and renal system. Human ortholog(s) of this gene implicated in hematologic cancer (multiple) and thrombocytopenia. Orthologous to human ETV6 (ETS variant transcription factor 6).
- Genome Resources
-
- Alliance (1)
- Gene:114444 (1)
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
-
- GEO (1) Expression Atlas (1) Single Cell Expression Atlas (1) Daniocell (1)
- Thisse Expression Data
-
- MGC:55785 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 6 figures from Rasighaemi et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| acute myeloid leukemia | Alliance | Leukemia, acute myeloid, somatic | 601626 |
| Thrombocytopenia 5 | 616216 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000418 | Ets domain |
| Domain | IPR003118 | Pointed domain |
| Family | IPR046328 | ETS family |
| Homologous_superfamily | IPR013761 | Sterile alpha motif/pointed domain superfamily |
| Homologous_superfamily | IPR036388 | Winged helix-like DNA-binding domain superfamily |
| Homologous_superfamily | IPR036390 | Winged helix DNA-binding domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Ets domain | ETS family | Pointed domain | Sterile alpha motif/pointed domain superfamily | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q7ZU22 | InterPro | 444 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance