ZFIN ID: ZDB-GENE-010724-6
Gene Name: fumarate hydratase
Gene Symbol: fh    Nomenclature History

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Previous Names: im:7152785, ns:zf-e152, zf-e152, zgc:66253, zgc:77498

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 12 Mapping Details/Browsers
Description: Predicted to have fumarate hydratase activity. Predicted to be involved in fumarate metabolic process; malate metabolic process; and tricarboxylic acid cycle. Predicted to localize to the mitochondrion. Human ortholog(s) of this gene implicated in fumarase deficiency. Is expressed in several structures, including adaxial cell; alar plate midbrain region; immature eye; liver; and optic tectum. Orthologous to human FH (fumarate hydratase).
Genome Resources: Alliance (1),  Gene:393938 (1),  Ensembl(GRCz11):ENSDARG00000075132 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 6 figures (11 images) from Thisse et al., 2004 [IMAGE:7152785]
Wild-type Stages, Structures: Segmentation:1-4 somites (10.33h-11.66h) to Hatching:Long-pec (48.0h-60.0h)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la027368Tg Transgenic Insertion Unknown Unknown DNA
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
CRISPR1-fh
2
CRISPR2-fh
2
CRISPR3-fh
1
CRISPR4-fh
1
CRISPR5-fh
1
CRISPR6-fh
2
CRISPR7-fh
2
TALEN1-fh
3
PHENOTYPE
Data: Fig. S4 from Hwang et al., 2013
Observed in:
DISEASE ASSOCIATED WITH fh HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
fumarase deficiency Alliance Fumarase deficiency 606812
Leiomyomatosis and renal cell cancer 150800
DISEASE ASSOCIATED WITH fh VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process fumarate metabolic process (more)
Cellular Component chromosome (more)
Molecular Function fumarate hydratase activity (more)
GO Terms (all 13)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Conserved_site IPR020557 Fumarate lyase, conserved site
Domain IPR018951 Fumarase C, C-terminal
Domain IPR022761 Fumarate lyase, N-terminal
Family IPR000362 Fumarate lyase family
Family IPR005677 Fumarate hydratase, class II
Homologous_superfamily IPR008948 L-Aspartase-like
Homologous_superfamily IPR024083 Fumarase/histidase, N-terminal
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA fh-201 (1)    Ensembl 1741
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
CONSTRUCTS WITH SEQUENCES FROM fh No data available
MARKER RELATIONSHIPS
fh Contained in: [Fosmid] ZFOS-659F11 (1)
fh Encodes: [EST] IMAGE:7152785 (1), zf-e152 (1)
[cDNA] MGC:66253 (1), MGC:77498 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_200963 (1) 1759 nt
Genomic GenBank:CU694363 (1) 36698 nt
Select Tool
Polypeptide UniProtKB:F1QWR4 (1) 509 aa
Sequence Information (all 23)
ORTHOLOGY for fh ( Chr: 12 )
CITATIONS (37)