Gene

fh

ID
ZDB-GENE-010724-6
Name
fumarate hydratase
Symbol
fh Nomenclature History
Previous Names
  • im:7152785
  • ns:zf-e152
  • zf-e152
  • zgc:66253
  • zgc:77498
Type
protein_coding_gene
Location
Chr: 12 Mapping Details/Browsers
Description
Predicted to have fumarate hydratase activity. Predicted to be involved in fumarate metabolic process; malate metabolic process; and tricarboxylic acid cycle. Predicted to localize to mitochondrion. Is expressed in several structures, including adaxial cell; alar plate midbrain region; immature eye; liver; and optic tectum. Human ortholog(s) of this gene implicated in fumarase deficiency. Orthologous to human FH (fumarate hydratase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
6 figures from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Hwang et al., 2013
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With fh Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
fumarase deficiency Alliance Fumarase deficiency 606812
Leiomyomatosis and renal cell cancer 150800
Associated With fh Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR020557 Fumarate lyase, conserved site
Domain IPR018951 Fumarase C, C-terminal
Domain IPR022761 Fumarate lyase, N-terminal
Family IPR000362 Fumarate lyase family
Family IPR005677 Fumarate hydratase, class II
Homologous_superfamily IPR008948 L-Aspartase-like
Homologous_superfamily IPR024083 Fumarase/histidase, N-terminal
Domain Details Per Protein
Protein Length Fumarase C, C-terminal Fumarase/histidase, N-terminal Fumarate hydratase, class II Fumarate lyase, conserved site Fumarate lyase family Fumarate lyase, N-terminal L-Aspartase-like
UniProtKB:F1QWR4 509
UniProtKB:Q7SX99 509
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations