Gene

mpz

ID
ZDB-GENE-010724-4
Name
myelin protein zero
Symbol
mpz Nomenclature History
Previous Names
  • p0
  • sc:d0186
  • wu:fc04b11
  • wu:fi30g06
  • zgc:103775
Type
protein_coding_gene
Location
Chr: 2 Mapping Details/Browsers
Description
Localizes to myelin sheath. Is expressed in several structures, including Rohon-Beard neurons; basal plate midbrain region; central nervous system; cranial nerve; and oligodendrocyte. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease (multiple). Orthologous to human MPZ (myelin protein zero).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
36 figures from 18 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With mpz Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Charcot-Marie-Tooth disease dominant intermediate D Alliance Charcot-Marie-Tooth disease, dominant intermediate D 607791
Charcot-Marie-Tooth disease type 1B Alliance Charcot-Marie-Tooth disease, type 1B 118200
Charcot-Marie-Tooth disease type 2I Alliance Charcot-Marie-Tooth disease, type 2I 607677
Charcot-Marie-Tooth disease type 2J Alliance Charcot-Marie-Tooth disease, type 2J 607736
Charcot-Marie-Tooth disease type 3 Alliance Dejerine-Sottas disease 145900
Hypomyelinating neuropathy, congenital, 2 618184
Roussy-Levy syndrome 180800
Associated With mpz Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR003599 Immunoglobulin subtype
Domain IPR007110 Immunoglobulin-like domain
Domain IPR013106 Immunoglobulin V-set domain
Family IPR000920 Myelin P0 protein-related
Family IPR029869 Myelin protein P0
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR036179 Immunoglobulin-like domain superfamily
Domain Details Per Protein
Protein Length Immunoglobulin-like domain Immunoglobulin-like domain superfamily Immunoglobulin-like fold Immunoglobulin subtype Immunoglobulin V-set domain Myelin P0 protein-related Myelin protein P0
UniProtKB:Q5U3C5 203
UniProtKB:F1QZP8 165
UniProtKB:F1QYN7 201
UniProtKB:A0A0R4IWG8 202
UniProtKB:F1D6B3 212
UniProtKB:A0A2R8QN30 228
UniProtKB:F1D6B1 228
UniProtKB:B0S5Q7 203
UniProtKB:A4JYM2 146
UniProtKB:F1D6B2 206
UniProtKB:Q8JFG6 203
UniProtKB:A4JYE8 142
UniProtKB:A0A0R4IS04 212
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-mpz Rabbit
  • IHC
  • WB
2
Ab2-mpz Rabbit
  • IHC
  • WB
1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations