ZFIN ID: ZDB-GENE-010724-4
Gene Name: myelin protein zero
Gene Symbol: mpz    Nomenclature History

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Previous Names: p0, sc:d0186, wu:fc04b11, wu:fi30g06, zgc:103775

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 2 Mapping Details/Browsers
Description: Localizes to myelin sheath. Is expressed in several structures, including Rohon-Beard neurons; basal plate midbrain region; central nervous system; cranial nerve; and oligodendrocyte. Human ortholog(s) of this gene implicated in neuromuscular disease (multiple). Orthologous to human MPZ (myelin protein zero).
Genome Resources: Alliance (1),  Gene:114417 (1),  Ensembl(GRCz11):ENSDARG00000038609 (2)
GENE EXPRESSION
All Expression Data: 36 figures from 18 publications
Directly Submitted Expression Data: 7 figures (15 images) from Thisse et al., 2004 [MGC:103775]
Wild-type Stages, Structures: Gastrula:90%-epiboly (9.0h-10.0h) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa62 Point Mutation Unknown Premature Stop ENU
PHENOTYPE No data available
DISEASE ASSOCIATED WITH mpz HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Charcot-Marie-Tooth disease dominant intermediate D Alliance Charcot-Marie-Tooth disease, dominant intermediate D 607791
Charcot-Marie-Tooth disease type 1B Alliance Charcot-Marie-Tooth disease, type 1B 118200
Charcot-Marie-Tooth disease type 2I Alliance Charcot-Marie-Tooth disease, type 2I 607677
Charcot-Marie-Tooth disease type 2J Alliance Charcot-Marie-Tooth disease, type 2J 607736
Charcot-Marie-Tooth disease type 3 Alliance Dejerine-Sottas disease 145900
Hypomyelinating neuropathy, congenital, 2 618184
Roussy-Levy syndrome 180800
DISEASE ASSOCIATED WITH mpz VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Cellular Component myelin sheath (more)
GO Terms (all 4)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA mpz-202 (1)    Ensembl 2344
mpz-203 (1)    Ensembl 1389
mpz-204 (1)    Ensembl 943
ncRNA mpz-002 (1)    Ensembl 598
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES
Name Type Isotype Host Organism Assay Source Publications
Ab1-mpz Rabbit IHC, WB 2
Ab2-mpz Rabbit IHC, WB 1
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM mpz
Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
Tg1(mpz:mpz-EGFP) mpz EGFPmpz Danio rerio 4 2
Tg2(mpz:mpz-EGFP) mpz EGFPmpz Danio rerio 1 2
Tg3(mpz:mpz-EGFP) mpz EGFPmpz Danio rerio 1 2
Tg4(mpz:mpz-EGFP) mpz EGFPmpz Danio rerio 1 2
MARKER RELATIONSHIPS
mpz Contained in: [BAC] DKEYP-35B8 (1)
mpz Contains: [SNP] rs3727652 (1)
mpz Encodes: [EST] fc04b11 (1), fi30g06 (1)
[cDNA] cssl:d186 (1), cssl:d806 (1), MGC:103775 (1), MGC:191219 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_194361 (1) 2339 nt
Genomic GenBank:BX294126 (1) 179476 nt
Select Tool
Polypeptide UniProtKB:A0A2R8QN30 (1) 228 aa
Sequence Information (all 51)
ORTHOLOGY for mpz ( Chr: 2 )
CITATIONS (57)