Gene

neurog3

ID
ZDB-GENE-010608-4
Name
neurogenin 3
Symbol
neurog3 Nomenclature History
Previous Names
  • atoh4
  • ngn2 (1)
  • ngn3 (1)
  • ngn3a (1)
  • Zath4b (1)
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in neuron differentiation and regulation of transcription by RNA polymerase II. Predicted to localize to nucleus. Is expressed in endocrine pancreas; gut; and hypothalamus. Human ortholog(s) of this gene implicated in congenital malabsorptive diarrhea 4; glucose intolerance; and type 2 diabetes mellitus. Orthologous to human NEUROG3 (neurogenin 3).
Genome Resources
Note
None
Expression
All Expression Data
4 figures from 4 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With neurog3 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
congenital malabsorptive diarrhea 4 Alliance Diarrhea 4, malabsorptive, congenital 610370
Associated With neurog3 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Family IPR032656 Neurogenin-3
Homologous_superfamily IPR036638 Helix-loop-helix DNA-binding domain superfamily
Domain Details Per Protein
Protein Length Helix-loop-helix DNA-binding domain superfamily Myc-type, basic helix-loop-helix (bHLH) domain Neurogenin-3
UniProtKB:B3DFN6 208
UniProtKB:Q9DG56 208
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations