Gene
neurod2
- ID
- ZDB-GENE-010608-3
- Name
- neuronal differentiation 2
- Symbol
- neurod2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and E-box binding activity. Predicted to be involved in axon development; positive regulation of transcription by RNA polymerase II; and sensory organ development. Predicted to act upstream of or within cell differentiation; nervous system development; and regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in granule cell. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 72. Orthologous to human NEUROD2 (neuronal differentiation 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| developmental and epileptic encephalopathy 72 | Alliance | Developmental and epileptic encephalopathy 72 | 618374 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR011598 | Myc-type, basic helix-loop-helix (bHLH) domain |
| Domain | IPR022575 | Neurogenic differentiation factor, domain of unknown function |
| Family | IPR016637 | Neurogenic differentiation factor NeuroD |
| Family | IPR050359 | Basic helix-loop-helix transcription factors |
| Homologous_superfamily | IPR036638 | Helix-loop-helix DNA-binding domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Basic helix-loop-helix transcription factors | Helix-loop-helix DNA-binding domain superfamily | Myc-type, basic helix-loop-helix (bHLH) domain | Neurogenic differentiation factor, domain of unknown function | Neurogenic differentiation factor NeuroD |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q9W6C8 | InterPro | 363 | |||||
| UniProtKB:A0AB32TZY3 | InterPro | 363 | |||||
| UniProtKB:A0AB32U2E8 | InterPro | 373 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
neurod2-201
(1)
|
Ensembl | 1,604 nt |
Interactions and Pathways
No data available
Plasmids
No data available