Gene

igf1

ID
ZDB-GENE-010607-2
Name
insulin-like growth factor 1
Symbol
igf1 Nomenclature History
Previous Names
  • IGF-1a (1)
  • IGF-I (1)
  • igf1a (1)
Type
protein_coding_gene
Location
Chr: 4 Mapping Details/Browsers
Description
Exhibits insulin-like growth factor receptor binding activity. Involved in dorsal/ventral pattern formation and positive regulation of cell population proliferation. Predicted to localize to extracellular space. Is expressed in several structures, including digestive system; eye; female organism; musculature system; and solid lens vesicle. Human ortholog(s) of this gene implicated in several diseases, including acne; artery disease (multiple); diabetes mellitus (multiple); myopia; and neurodegenerative disease (multiple). Orthologous to human IGF1 (insulin like growth factor 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
40 figures from 33 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Serbanovic-Canic et al., 2017
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With igf1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Growth retardation with deafness and mental retardation due to IGF1 deficiency 608747
Associated With igf1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR022353 Insulin, conserved site
Domain IPR016179 Insulin-like
Family IPR022341 Insulin-like growth factor I
Family IPR022350 Insulin-like growth factor
Family IPR022352 Insulin family
Homologous_superfamily IPR036438 Insulin-like superfamily
Domain Details Per Protein
Protein Length Insulin, conserved site Insulin family Insulin-like Insulin-like growth factor Insulin-like growth factor I Insulin-like superfamily
UniProtKB:Q90VV9 161
UniProtKB:Q8QGA1 16
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations