Gene

mafaa

ID
ZDB-GENE-010605-3
Name
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog Aa
Symbol
mafaa Nomenclature History
Previous Names
  • mafa
  • mafl
  • SMaf1 (1)
Type
protein_coding_gene
Location
Chr: 6 Mapping Details/Browsers
Description
Exhibits sequence-specific DNA binding activity. Predicted to be involved in multicellular organism development and regulation of transcription, DNA-templated. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Is expressed in myotome; nervous system; neural tube; and somite. Orthologous to human MAFA (MAF bZIP transcription factor A).
Genome Resources
Note
This gene, the ortholog of the human MAFA gene, does not appear to have a genome duplicate. It was assigned the 'a' genome duplicate nomenclature to allow accommodation of zebrafish gene symbols mafa and mafb for the orthologs (and genome duplicates) of human MAF.
Comparative Information
Expression
All Expression Data
6 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With mafaa Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Insulinomatosis and diabetes mellitus 147630
Associated With mafaa Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR004826 Basic leucine zipper domain, Maf-type
Domain IPR004827 Basic-leucine zipper domain
Domain IPR013592 Maf transcription factor, N-terminal
Family IPR024874 Transcription factor Maf family
Family IPR028562 Transcription factor MafA
Homologous_superfamily IPR008917 Transcription factor, Skn-1-like, DNA-binding domain superfamily
Domain Details Per Protein
Protein Length Basic-leucine zipper domain Basic leucine zipper domain, Maf-type Maf transcription factor, N-terminal Transcription factor MafA Transcription factor Maf family Transcription factor, Skn-1-like, DNA-binding domain superfamily
UniProtKB:A3KMR8 315
UniProtKB:B3DGB3 315
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations