ZFIN ID: ZDB-GENE-010605-3
Gene Name: v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog Aa
Gene Symbol: mafaa    Nomenclature History

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Previous Names: mafa, mafl, SMaf1 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 6 Mapping Details/Browsers
Description: Exhibits sequence-specific DNA binding activity. Predicted to be involved in multicellular organism development and regulation of transcription, DNA-templated. Predicted to localize to nucleus. Is expressed in myotome; nervous system; neural tube; and somite. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human MAFA (MAF bZIP transcription factor A).
Genome Resources: Alliance (1),  Gene:100000492 (1),  Ensembl(GRCz11):ENSDARG00000044155 (2)
Note: This gene, the ortholog of the human MAFA gene, does not appear to have a genome duplicate. It was assigned the 'a' genome duplicate nomenclature to allow accommodation of zebrafish gene symbols mafa and mafb for the orthologs (and genome duplicates) of human MAF.
GENE EXPRESSION
All Expression Data: 6 figures from 2 publications
Directly Submitted Expression Data: 5 figures (8 images) from Thisse et al., 2004 [IMAGE:6911585]
Wild-type Stages, Structures: Segmentation:5-9 somites (11.66h-14.0h) to Hatching:Long-pec (48.0h-60.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa20729 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH mafaa HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Insulinomatosis and diabetes mellitus 147630
    DISEASE ASSOCIATED WITH mafaa VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process multicellular organism development (more)
    Cellular Component host cell nucleus (more)
    Molecular Function sequence-specific DNA binding (more)
    GO Terms (all 8)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA mafaa-201 (1)    Ensembl 3959
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM mafaa No data available
    MARKER RELATIONSHIPS
    mafaa Contained in: [BAC] CH73-269F15 (1)
    mafaa Encodes: [EST] IMAGE:6911585 (1)
    [cDNA] MGC:158153 (1), MGC:193922 (1), MGC:193959 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001082940 (1) 4064 nt
    Genomic GenBank:BX470204 (1) 185190 nt
    Select Tool
    Polypeptide UniProtKB:A3KMR8 (1) 315 aa
    Sequence Information (all 25)
    ORTHOLOGY for mafaa ( Chr: 6 )
    CITATIONS (29)