ZFIN ID: ZDB-GENE-010410-2
Gene Name: glycine receptor, beta a
Gene Symbol: glrba    Nomenclature History

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Previous Names: glrb1 (1), glrb, [b]Z (1), etID17582.1 (1), fj42f03, GlyR [b]Z (1), wu:fj42f03 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 1 Mapping Details/Browsers
Description: Predicted to contribute to extracellularly glycine-gated chloride channel activity and glycine binding activity. Predicted to be involved in several processes, including chloride transmembrane transport; glycinergic synaptic transmission; and neuropeptide signaling pathway. Predicted to localize to integral component of plasma membrane; neuron projection; and synapse. Is expressed in hindbrain and spinal cord. Human ortholog(s) of this gene implicated in hyperekplexia 2. Orthologous to human GLRB (glycine receptor beta).
Genome Resources: Alliance (1),  Gene:83412 (1),  Ensembl(GRCz11):ENSDARG00000052782 (1)
GENE EXPRESSION
All Expression Data: 6 figures from 4 publications
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa11272 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa19479 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-glrba N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH glrba HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    hyperekplexia 2 Alliance Hyperekplexia 2 614619
    DISEASE ASSOCIATED WITH glrba VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process chloride transport (more)
    Cellular Component integral component of membrane (more)
    Molecular Function extracellular ligand-gated ion channel activity (more)
    GO Terms (all 24)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA glrba-201 (1)    Ensembl 2421
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM glrba No data available
    MARKER RELATIONSHIPS
    glrba Contained in: [BAC] CH73-280L8 (1), DKEY-251E24 (1) (order this)
    glrba Encodes: [EST] fj42f03 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131781 (1) 2426 nt
    Genomic GenBank:BX284619 (1) 196931 nt
    Select Tool
    Polypeptide UniProtKB:A0A2R8QRM1 (1) 499 aa
    Sequence Information (all 14)
    ORTHOLOGY for glrba ( Chr: 1 )
    CITATIONS (27)