ZFIN ID: ZDB-GENE-010410-2
Gene Name: glycine receptor, beta a
Gene Symbol: glrba    Nomenclature History

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Previous Names: glrb1 (1), glrb, [b]Z (1), etID17582.1 (1), fj42f03, GlyR [b]Z (1), wu:fj42f03 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 1 Mapping Details/Browsers
Description: Predicted to contribute to extracellularly glycine-gated chloride channel activity and glycine binding activity. Predicted to be involved in several processes, including chloride transmembrane transport; glycinergic synaptic transmission; and neuropeptide signaling pathway. Predicted to localize to the integral component of plasma membrane; neuron projection; and synapse. Human ortholog(s) of this gene implicated in hyperekplexia 2. Is expressed in hindbrain and spinal cord. Orthologous to human GLRB (glycine receptor beta).
Genome Resources: Alliance (1),  Gene:83412 (1),  Ensembl(GRCz11):ENSDARG00000052782 (1)
GENE EXPRESSION
All Expression Data: 5 figures from 3 publications
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa11272 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa19479 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-glrba N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH glrba HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    hyperekplexia 2 Alliance Hyperekplexia 2 614619
    DISEASE ASSOCIATED WITH glrba VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process chloride transport (more)
    Cellular Component integral component of membrane (more)
    Molecular Function extracellular ligand-gated ion channel activity (more)
    GO Terms (all 23)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
    Family IPR006201 Neurotransmitter-gated ion-channel
    Domain IPR006202 Neurotransmitter-gated ion-channel ligand-binding domain
    Family IPR008060 Glycine receptor beta
    Conserved_site IPR018000 Neurotransmitter-gated ion-channel, conserved site
    Homologous_superfamily IPR036719 Neurotransmitter-gated ion-channel transmembrane domain superfamily
    Homologous_superfamily IPR036734 Neurotransmitter-gated ion-channel ligand-binding domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA glrba-201 (1)    Ensembl 2421
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM glrba No data available
    MARKER RELATIONSHIPS
    glrba Contained in: [BAC] CH73-280L8 (1), DKEY-251E24 (1) (order this)
    glrba Encodes: [EST] fj42f03 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131781 (1) 2426 bp
    Genomic GenBank:BX284619 (1) 196931 bp
    Select Tool
    Polypeptide UniProtKB:A0A2R8QRM1 (1) 499 aa
    Sequence Information (all 14)
    ORTHOLOGY for glrba ( Chr: 1 )
    CITATIONS (26)