Gene

glrba

ID
ZDB-GENE-010410-2
Name
glycine receptor, beta a
Symbol
glrba Nomenclature History
Previous Names
  • glrb1 (1)
  • glrb
  • [b]Z (1)
  • etID17582.1 (1)
  • fj42f03
  • GlyR [b]Z (1)
  • wu:fj42f03 (1)
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Predicted to contribute to extracellularly glycine-gated chloride channel activity and glycine binding activity. Predicted to be involved in several processes, including chloride transmembrane transport; glycinergic synaptic transmission; and neuropeptide signaling pathway. Predicted to localize to integral component of plasma membrane; neuron projection; and synapse. Is expressed in hindbrain and spinal cord. Human ortholog(s) of this gene implicated in hyperekplexia 2. Orthologous to human GLRB (glycine receptor beta).
Genome Resources
Note
None
Expression
All Expression Data
7 figures from 5 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With glrba Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
hyperekplexia 2 Alliance Hyperekplexia 2 614619
Associated With glrba Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018000 Neurotransmitter-gated ion-channel, conserved site
Domain IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
Domain IPR006202 Neurotransmitter-gated ion-channel ligand-binding domain
Family IPR006201 Neurotransmitter-gated ion-channel
Family IPR008060 Glycine receptor beta
Homologous_superfamily IPR036719 Neurotransmitter-gated ion-channel transmembrane domain superfamily
Homologous_superfamily IPR036734 Neurotransmitter-gated ion-channel ligand-binding domain superfamily
Domain Details Per Protein
Protein Length Glycine receptor beta Neurotransmitter-gated ion-channel Neurotransmitter-gated ion-channel, conserved site Neurotransmitter-gated ion-channel ligand-binding domain Neurotransmitter-gated ion-channel ligand-binding domain superfamily Neurotransmitter-gated ion-channel transmembrane domain Neurotransmitter-gated ion-channel transmembrane domain superfamily
UniProtKB:A0A2R8QRM1 499
UniProtKB:Q9DES8 498
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations