Gene

siah1

ID
ZDB-GENE-010319-31
Name
siah E3 ubiquitin protein ligase 1
Symbol
siah1 Nomenclature History
Previous Names
  • id:ibd2635
  • zgc:56026
Type
protein_coding_gene
Location
Chr: 18 Mapping Details/Browsers
Description
Predicted to have ubiquitin conjugating enzyme binding activity; ubiquitin protein ligase activity; and zinc ion binding activity. Predicted to be involved in neuron apoptotic process and proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to localize to cytosol and nucleus. Is expressed in germ ring; myotome; and nervous system. Orthologous to human SIAH1 (siah E3 ubiquitin protein ligase 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
8 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With siah1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Buratti-Harel syndrome 619314
Associated With siah1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001841 Zinc finger, RING-type
Domain IPR013010 Zinc finger, SIAH-type
Domain IPR018121 Seven-in-absentia protein, TRAF-like domain
Domain IPR049548 E3 ubiquitin-protein ligase Sina-like, RING finger
Family IPR004162 E3 ubiquitin-protein ligase SINA-like, animal
Homologous_superfamily IPR008974 TRAF-like
Homologous_superfamily IPR013083 Zinc finger, RING/FYVE/PHD-type
Domain Details Per Protein
Protein Length E3 ubiquitin-protein ligase SINA-like, animal E3 ubiquitin-protein ligase Sina-like, RING finger Seven-in-absentia protein, TRAF-like domain TRAF-like Zinc finger, RING/FYVE/PHD-type Zinc finger, RING-type Zinc finger, SIAH-type
UniProtKB:A0A0H2UKD5 286
UniProtKB:Q7ZVG6 282
UniProtKB:A0A0R4IPD0 334
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations