ZFIN ID: ZDB-GENE-010306-1
Gene Name: cytochrome P450, family 11, subfamily A, polypeptide 1
Gene Symbol: cyp11a1
Sequence Ontology ID : SO:0000704

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Previous Names: cb957 (1), P450scc (1), scc (1), side-chain cleavage enzyme (1), wu:fj97d10

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(Including Attributions)
Location: Chr: 25 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Predicted to have cholesterol monooxygenase (side-chain-cleaving) activity; involved in several processes, including C21-steroid hormone biosynthetic process, epiboly, and positive regulation of  ...
GENE EXPRESSION
All Expression Data: 37 figures from 23 publications
Directly Submitted Expression Data: 6 figures (11 images) from Thisse et al., 2001 [cb957]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ihb156 Insertion Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC, ZKO consortium) (order this)
  • ihb157 Small Deletion Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC, ZKO consortium) (order this)
  • sa38075 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Targeting reagents:
    PHENOTYPE
    Data: 6 figures from 4 publications
    Observed in:
    DISEASE ASSOCIATED WITH cyp11a1 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    congenital adrenal insufficiency Adrenal insufficiency, congenital, with 46XY sex reversal, partial or complete 613743
    DISEASE ASSOCIATED WITH cyp11a1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process positive regulation of microtubule polymerization (more)
    Cellular Component mitochondrion (more)
    Molecular Function cholesterol monooxygenase (side-chain-cleaving) activity (more)
    GO Terms (all 18)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001128 (1)
  • InterPro:IPR002399 (1)
  • InterPro:IPR002401 (1)
  • InterPro:IPR017972 (1)
  • InterPro:IPR033283 (1)
  • InterPro:IPR036396 (1)
  • PROSITE:PS00086 (1)
  • Pfam:PF00067 (1)
  • EC:1.14.15.6 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA cyp11a1-201 (1) 2185
    cyp11a1-203 (1) 833
    cyp11a1-204 (1) 776
    cyp11a1-205 (1) 884
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM cyp11a1 No data available
    MARKER RELATIONSHIPS
    cyp11a1Contained in: [BAC] DKEYP-91C1 (1)
    cyp11a1Encodes: [EST] cb957 (1) (order this), fj97d10
    [cDNA] MGC:66431 (1) (order this), MGC:174439 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_152953 (1) 2212bp
    Genomic GenBank:AL929050 (1) 196743bp
    Select Tool
    Polypeptide UniProtKB:A8KC03 (1) 509aa
    Sequence Clusters UniGene:80336 (1)
    Sequence Information (all 24)
    OTHER cyp11a1 GENE PAGES
  • Alliance (1)
  • Gene:80374 (1)
  • VEGA:OTTDARG00000039421 (1)
  • ORTHOLOGY for cyp11a1 (Chr: 25)
    CITATIONS (126)