Gene

cyp11a1

ID

ZDB-GENE-010306-1

Name

cytochrome P450, family 11, subfamily A, polypeptide 1

Symbol

cyp11a1 Nomenclature History

Previous Names

cb957 (1)
P450scc (1)
scc (1)
side-chain cleavage enzyme (1)
wu:fj97d10

Type

protein_coding_gene

Location

Chr: 25 Mapping Details/Browsers

Description

Predicted to have cholesterol monooxygenase (side-chain-cleaving) activity. Involved in several processes, including C21-steroid hormone biosynthetic process; epiboly; and positive regulation of microtubule polymerization. Predicted to localize to mitochondrial inner membrane. Is expressed in brain; endocrine system; female organism; interrenal primordium; and yolk syncytial layer. Human ortholog(s) of this gene implicated in congenital adrenal hyperplasia and congenital adrenal insufficiency. Orthologous to human CYP11A1 (cytochrome P450 family 11 subfamily A member 1).

Genome Resources

Note

None

Expression

All Expression Data

46 figures from 28 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

Thisse Expression Data

cb957 (11 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 8 figures from 5 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cyp11a1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
congenital adrenal insufficiency	Alliance	Adrenal insufficiency, congenital, with 46XY sex reversal, partial or complete	613743

Associated With cyp11a1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017972	Cytochrome P450, conserved site
Family	IPR001128	Cytochrome P450
Family	IPR002399	Cytochrome P450, mitochondrial
Family	IPR002401	Cytochrome P450, E-class, group I
Family	IPR033283	Cholesterol side-chain cleavage enzyme, mitochondrial
Homologous_superfamily	IPR036396	Cytochrome P450 superfamily

Domain Details Per Protein

Protein	Length	Cholesterol side-chain cleavage enzyme, mitochondrial	Cytochrome P450	Cytochrome P450, conserved site	Cytochrome P450, E-class, group I	Cytochrome P450, mitochondrial	Cytochrome P450 superfamily
UniProtKB:X1WFM9 InterPro	235
UniProtKB:X1WH33 InterPro	266
UniProtKB:Q7SYJ6 InterPro	509
UniProtKB:Q8JH93 InterPro	509
UniProtKB:A8KC03 InterPro	509
UniProtKB:X1WBB6 InterPro	245

Transcripts

Genome Browsers

Type	Name	Length (nt)	Analysis
mRNA	cyp11a1-201 (1) Ensembl	2185 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	cyp11a1-203 (1) Ensembl	833 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	cyp11a1-204 (1) Ensembl	776 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	cyp11a1-205 (1) Ensembl	884 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Gene Tree: Ensembl

Citations