Gene

cyp11a1.1

ID

ZDB-GENE-010306-1

Name

cytochrome P450 family 11 subfamily A member 1, tandem duplicate 1

Symbol

cyp11a1.1 Nomenclature History

Previous Names

cb957 (1)
cyp11a1
scc (1)
P450scc (1)
side-chain cleavage enzyme (1)
wu:fj97d10

Type

protein_coding_gene

Location

Chr: 25 Mapping Details/Browsers

Description

Predicted to enable cholesterol monooxygenase (side-chain-cleaving) activity. Acts upstream of or within several processes, including C21-steroid hormone biosynthetic process; determination of heart left/right asymmetry; and positive regulation of microtubule polymerization. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial inner membrane. Is expressed in several structures, including brain; endocrine system; interrenal primordium; male organism; and yolk syncytial layer. Human ortholog(s) of this gene implicated in congenital adrenal hyperplasia and congenital adrenal insufficiency. Orthologous to human CYP11A1 (cytochrome P450 family 11 subfamily A member 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

53 figures from 34 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb957 (11 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 9 figures from 6 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cyp11a1.1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
congenital adrenal insufficiency	Alliance	Adrenal insufficiency, congenital, with 46XY sex reversal, partial or complete	613743

Associated With cyp11a1.1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017972	Cytochrome P450, conserved site
Family	IPR001128	Cytochrome P450
Family	IPR002401	Cytochrome P450, E-class, group I
Family	IPR050479	Cytochrome P450, families 11 and 27
Homologous_superfamily	IPR036396	Cytochrome P450 superfamily

Domain Details Per Protein

Protein	Additional Resources	Length	Cytochrome P450	Cytochrome P450, conserved site	Cytochrome P450, E-class, group I	Cytochrome P450, families 11 and 27	Cytochrome P450 superfamily
UniProtKB:Q7SYJ6	InterPro	509

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	cyp11a1-201 (1) Ensembl	Ensembl	2,185 nt	Select Tool ZFIN BLAST
mRNA	cyp11a1-202 (1) Ensembl	Ensembl	2,235 nt	Select Tool ZFIN BLAST
mRNA	cyp11a1-203 (1) Ensembl	Ensembl	833 nt	Select Tool ZFIN BLAST
mRNA	cyp11a1-204 (1) Ensembl	Ensembl	776 nt	Select Tool ZFIN BLAST
mRNA	cyp11a1-205 (1) Ensembl	Ensembl	884 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations