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ZIRC
ZFIN ID: ZDB-GENE-010306-1
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Gene Name: cytochrome P450, family 11, subfamily A, polypeptide 1
Gene Symbol: cyp11a1    Nomenclature History

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Previous Names: cb957 (1), P450scc (1), scc (1), side-chain cleavage enzyme (1), wu:fj97d10

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 25 Mapping Details/Browsers
Description: Predicted to have cholesterol monooxygenase (side-chain-cleaving) activity. Involved in several processes, including C21-steroid hormone biosynthetic process; epiboly; and positive regulation of microtubule polymerization. Predicted to localize to the mitochondrial inner membrane. Human ortholog(s) of this gene implicated in congenital adrenal hyperplasia and congenital adrenal insufficiency. Is expressed in brain; endocrine system; female organism; interrenal primordium; and yolk syncytial layer. Orthologous to human CYP11A1 (cytochrome P450 family 11 subfamily A member 1).
Genome Resources: Alliance (1),  Gene:80374 (1),  Ensembl(GRCz11):ENSDARG00000002347 (1)
GENE EXPRESSION
All Expression Data: 41 figures from 24 publications
Directly Submitted Expression Data: 6 figures (11 images) from Thisse et al., 2001 [cb957]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ihb156 Insertion Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
    • ihb157 Small Deletion Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
    • sa38075 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-cyp11a1 1
    MO1-cyp11a1 N/A 5
    MO2-cyp11a1 N/A 1
    MO3-cyp11a1 N/A 1
    PHENOTYPE
    Data: 6 figures from 4 publications
    Observed in:
    DISEASE ASSOCIATED WITH cyp11a1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    congenital adrenal insufficiency Alliance Adrenal insufficiency, congenital, with 46XY sex reversal, partial or complete 613743
    DISEASE ASSOCIATED WITH cyp11a1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process positive regulation of microtubule polymerization (more)
    Cellular Component mitochondrion (more)
    Molecular Function cholesterol monooxygenase (side-chain-cleaving) activity (more)
    GO Terms (all 22)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001128 (1)
  • InterPro:IPR002399 (1)
  • InterPro:IPR002401 (1)
  • InterPro:IPR017972 (1)
  • InterPro:IPR033283 (1)
  • InterPro:IPR036396 (1)
  • PROSITE:PS00086 (1)
  • Pfam:PF00067 (1)
  • EC:1.14.15.6 (1)
    • TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cyp11a1-201 (1)    Ensembl 2185
    Select Tool
    cyp11a1-203 (1)    Ensembl 833
    Select Tool
    cyp11a1-204 (1)    Ensembl 776
    Select Tool
    cyp11a1-205 (1)    Ensembl 884
    Select Tool
    Browsers: UCSC,  NCBI,  Ensembl,  ZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cyp11a1 No data available
    MARKER RELATIONSHIPS
    cyp11a1 Contained in: [BAC] DKEYP-91C1 (1)
    cyp11a1 Encodes: [EST] cb957 (1) (order this), fj97d10
    [cDNA] MGC:66431 (1) (order this), MGC:174439 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_152953 (1) 2212 bp
    Select Tool
    Genomic GenBank:AL929050 (1) 196743 bp
    Select Tool
    Polypeptide UniProtKB:A8KC03 (1) 509 aa
    Select Tool
    Sequence Clusters UniGene:80336 (1)
    Sequence Information (all 24)
    ORTHOLOGY for cyp11a1 ( Chr: 25 )
    CITATIONS (133)