ZFIN ID: ZDB-GENE-010302-2
Gene Name: forkhead box C1b
Gene Symbol: foxc1b    Nomenclature History

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Previous Name: id:ibd5079 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 20 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in several processes, including animal organ development; regulation of platelet-derived growth factor receptor-alpha signaling pathway; and vasculature development. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in Axenfeld-Rieger syndrome; Axenfeld-Rieger syndrome type 3; anterior segment dysgenesis 3; and glaucoma. Is expressed in several structures, including fin bud; head; paraxial mesoderm; periocular mesenchyme; and vasculature. Orthologous to human FOXC1 (forkhead box C1).
Genome Resources: Alliance (1),  Gene:79375 (1),  Ensembl(GRCz11):ENSDARG00000055398 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
el620 Small Deletion Unknown Unknown CRISPR
ua1018 Small Deletion Unknown Unknown CRISPR
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
CRISPR1-foxc1b
1
CRISPR2-foxc1b 2
CRISPR3-foxc1b
1
CRISPR4-foxc1b 1
MO1-foxc1b N/A 11
MO2-foxc1b N/A 3
DISEASE ASSOCIATED WITH foxc1b HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
anterior segment dysgenesis 3 Alliance Anterior segment dysgenesis 3, multiple subtypes 601631
Axenfeld-Rieger syndrome type 3 Alliance Axenfeld-Rieger syndrome, type 3 602482
iridogoniodysgenesis syndrome Alliance Anterior segment dysgenesis 3, multiple subtypes 601631
DISEASE ASSOCIATED WITH foxc1b VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process blood vessel development (more)
Cellular Component nucleus (more)
Molecular Function DNA binding (more)
GO Terms (all 18)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA foxc1b-201 (1)    Ensembl 1955
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM foxc1b
Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
Tg(-5foxc1b:GAL4-VP16) foxc1b GAL4VP16 Danio rerio 1 1
Tg(foxc1b:EGFP) foxc1b EGFP Danio rerio 1 4
Tg(foxc1b:Eos) foxc1b Eos Danio rerio 1 1
tg(foxc1b:gal4ff,myl7:egfp) foxc1bmyl7 EGFPGAL4FF Danio rerio 1 1
MARKER RELATIONSHIPS
foxc1b Contained in: [BAC] DKEY-100F21 (1) (order this)
foxc1b Encodes: [EST] ibd5079 (1)
[cDNA] MGC:56256 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_131729 (1) 1967 nt
Genomic GenBank:BX510653 (1) 90530 nt
Select Tool
Polypeptide UniProtKB:Q9DE24 (1) 433 aa
Sequence Information (all 13)
ORTHOLOGY for foxc1b ( Chr: 20 )
CITATIONS (55)