Gene

ctbp1

ID
ZDB-GENE-010130-1
Name
C-terminal binding protein 1
Symbol
ctbp1 Nomenclature History
Previous Names
  • CtBP1 (1)
  • wu:fi43a11
Type
protein_coding_gene
Location
Chr: 14 Mapping Details/Browsers
Description
Predicted to have NAD binding activity; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; and transcription corepressor activity. Involved in retinoic acid receptor signaling pathway. Predicted to localize to nucleus. Orthologous to human CTBP1 (C-terminal binding protein 1).
Genome Resources
Note
None
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
Fig. 5 from Delacruz et al., 2019
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ctbp1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Hypotonia, ataxia, developmental delay, and tooth enamel defect syndrome 617915
Associated With ctbp1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR029752 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1
Conserved_site IPR029753 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site
Domain IPR006139 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
Domain IPR006140 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain
Family IPR043322 C-terminal binding protein
Homologous_superfamily IPR036291 NAD(P)-binding domain superfamily
Domain Details Per Protein
Protein Length C-terminal binding protein D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1 NAD(P)-binding domain superfamily
UniProtKB:Q9DEG7 449
UniProtKB:Q7ZU55 449
UniProtKB:E9QEQ4 288
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations