ZFIN ID: ZDB-GENE-010126-1
Gene Name: neurotrophic tyrosine kinase, receptor, type 2a
Gene Symbol: ntrk2a    Nomenclature History

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Previous Names: trkB1 (1), si:ch211-148p15.2

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 8 Mapping Details/Browsers
Description: Predicted to have brain-derived neurotrophic factor binding activity and brain-derived neurotrophic factor-activated receptor activity. Predicted to be involved in several processes, including cellular response to brain-derived neurotrophic factor stimulus; regulation of intracellular signal transduction; and trans-synaptic signaling by neuropeptide, modulating synaptic transmission. Predicted to localize to axon; integral component of plasma membrane; and receptor complex. Is expressed in endoderm; mesoderm; nervous system; neural tube; and pharyngeal epithelium. Human ortholog(s) of this gene implicated in Alzheimer's disease; autistic disorder; early infantile epileptic encephalopathy 58; major depressive disorder; and morbid obesity. Orthologous to human NTRK2 (neurotrophic receptor tyrosine kinase 2).
Genome Resources: Alliance (1),  Gene:65090 (1),  Ensembl(GRCz11):ENSDARG00000059897 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la016423Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la016424Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa544 Point Mutation Unknown Premature Stop ENU
    sa12452 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa13707 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15536 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa27277 Point Mutation Unknown Premature Stop ENU
    sa30907 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34500 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa38713 Point Mutation Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa41298 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa41299 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-ntrk2a N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH ntrk2a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    early infantile epileptic encephalopathy 58 Alliance Epileptic encephalopathy, early infantile, 58 617830
    Obesity, hyperphagia, and developmental delay 613886
    DISEASE ASSOCIATED WITH ntrk2a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process phosphorylation (more)
    Cellular Component integral component of membrane (more)
    Molecular Function ATP binding (more)
    GO Terms (all 31)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ntrk2a-202 (1)    Ensembl 3735
    ncRNA ntrk2a-002 (1) 550
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ntrk2a No data available
    MARKER RELATIONSHIPS
    ntrk2a Contained in: [BAC] CH73-236B16 (1), CH211-148P15 (1)
    ntrk2a Encodes: [STS] zfish44906-4497e03.q1k
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001366554 (1)
    Genomic GenBank:CU468685 (1) 108280 nt
    Select Tool
    Polypeptide UniProtKB:B8JLJ1 (1) 784 aa
    Sequence Information (all 13)
    ORTHOLOGY for ntrk2a ( Chr: 8 )
    CITATIONS (36)