ZFIN ID: ZDB-GENE-001101-1
Gene Name: nitric oxide synthase 1 (neuronal)
Gene Symbol: nos1    Nomenclature History

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Previous Name: nNOS

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Predicted to have NADPH-hemoprotein reductase activity; coenzyme binding activity; and nitric-oxide synthase activity. Involved in several processes, including animal organ development; collateral sprouting; and nitric oxide mediated signal transduction. Predicted to localize to several cellular components, including cytosol; postsynaptic density; and vesicle membrane. Is expressed in brain; enteric nervous system; nitrergic neurons; spinal cord; and trunk. Human ortholog(s) of this gene implicated in Alzheimer's disease; Parkinson's disease; asthma; cystic fibrosis; and hypertrophic pyloric stenosis. Orthologous to human NOS1 (nitric oxide synthase 1).
Genome Resources: Alliance (1),  Gene:60658 (1),  Ensembl(GRCz11):ENSDARG00000068910 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la011122Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa11824 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa12337 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa14542 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa20353 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa26415 Point Mutation Unknown Splice Site ENU
    sa33543 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sh336 Indel Unknown Unknown TALEN
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-nos1 N/A 4
    MO2-nos1 N/A 4
    TALEN1-nos1 1
    DISEASE ASSOCIATED WITH nos1 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH nos1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process collateral sprouting (more)
    Cellular Component cytosol (more)
    Molecular Function calmodulin binding (more)
    GO Terms (all 30)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA nos1-203 (1)    Ensembl 4851
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab2-nos1 polyclonal IgG Rabbit Abcam plc
    5
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM nos1 No data available
    MARKER RELATIONSHIPS
    nos1 Contained in: [BAC] CH211-244P16 (1), DKEY-60F6 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131660 (1) 4552 nt
    Genomic GenBank:CR735143 (1) 147626 nt
    Select Tool
    Polypeptide UniProtKB:A0A0R4IQG7 (1) 1431 aa
    Sequence Information (all 15)
    ORTHOLOGY for nos1 ( Chr: 5 )
    CITATIONS (49)