Gene

nos1

ID
ZDB-GENE-001101-1
Name
nitric oxide synthase 1 (neuronal)
Symbol
nos1 Nomenclature History
Previous Names
  • nNOS
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Predicted to have NADPH-hemoprotein reductase activity; coenzyme binding activity; and nitric-oxide synthase activity. Involved in several processes, including animal organ development; collateral sprouting; and nitric oxide mediated signal transduction. Predicted to localize to several cellular components, including cytosol; postsynaptic density; and vesicle membrane. Is expressed in brain; enteric nervous system; nitrergic neurons; spinal cord; and trunk. Human ortholog(s) of this gene implicated in Alzheimer's disease; Parkinson's disease; asthma; cystic fibrosis; and hypertrophic pyloric stenosis. Orthologous to human NOS1 (nitric oxide synthase 1).
Genome Resources
Note
None
Expression
All Expression Data
11 figures from 8 publications
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
10 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With nos1 Human Ortholog
No data available
Associated With nos1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001094 Flavodoxin-like
Domain IPR001433 Oxidoreductase FAD/NAD(P)-binding
Domain IPR001478 PDZ domain
Domain IPR001709 Flavoprotein pyridine nucleotide cytochrome reductase
Domain IPR003097 Sulfite reductase [NADPH] flavoprotein alpha-component-like, FAD-binding
Domain IPR004030 Nitric oxide synthase, N-terminal
Domain IPR008254 Flavodoxin/nitric oxide synthase
Domain IPR017927 FAD-binding domain, ferredoxin reductase-type
Family IPR012144 Nitric-oxide synthase, eukaryote
Homologous_superfamily IPR017938 Riboflavin synthase-like beta-barrel
Homologous_superfamily IPR023173 NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain superfamily
Homologous_superfamily IPR029039 Flavoprotein-like superfamily
Homologous_superfamily IPR036034 PDZ superfamily
Homologous_superfamily IPR036119 Nitric oxide synthase, N-terminal domain superfamily
Homologous_superfamily IPR039261 Ferredoxin-NADP reductase (FNR), nucleotide-binding domain
Domain Details Per Protein
Protein Length FAD-binding domain, ferredoxin reductase-type Ferredoxin-NADP reductase (FNR), nucleotide-binding domain Flavodoxin-like Flavodoxin/nitric oxide synthase Flavoprotein-like superfamily Flavoprotein pyridine nucleotide cytochrome reductase NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain superfamily Nitric-oxide synthase, eukaryote Nitric oxide synthase, N-terminal Nitric oxide synthase, N-terminal domain superfamily Oxidoreductase FAD/NAD(P)-binding PDZ domain PDZ superfamily Riboflavin synthase-like beta-barrel Sulfite reductase [NADPH] flavoprotein alpha-component-like, FAD-binding
UniProtKB:Q800V0 1431
UniProtKB:Q9DG14 207
UniProtKB:A0A0R4IQG7 1431
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab2-nos1 polyclonal IgG Rabbit
Abcam plc
6
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations