ZFIN ID: ZDB-GENE-000926-1
Gene Name: atonal bHLH transcription factor 7
Gene Symbol: atoh7    Nomenclature History

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Previous Names: ath5 (1), lak, lakritz, Zath5 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Predicted to have DNA binding activity and protein dimerization activity. Involved in several processes, including positive regulation of neurogenesis; retina layer formation; and swimming behavior. Predicted to localize to nucleus. Is expressed in eye and immature eye. Human ortholog(s) of this gene implicated in persistent hyperplastic primary vitreous. Orthologous to human ATOH7 (atonal bHLH transcription factor 7).
Genome Resources: Alliance (1),  Gene:58216 (1),  Ensembl(GRCz11):ENSDARG00000069552 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa16352 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa35489 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • th241 Point Mutation Unknown Missense ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-atoh7
    1
    CRISPR2-atoh7
    1
    MO1-atoh7 N/A 13
    MO2-atoh7 N/A 1
    DISEASE ASSOCIATED WITH atoh7 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    persistent hyperplastic primary vitreous Alliance Persistent hyperplastic primary vitreous, autosomal recessive 221900
    DISEASE ASSOCIATED WITH atoh7 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process retina layer formation (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 18)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA atoh7-201 (1)    Ensembl 1045
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM atoh7
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(-7atoh7:GAL4-VP16) atoh7 GAL4VP16 Danio rerio 1 26
    Tg(atoh7:EGFP) atoh7 EGFP Danio rerio 1 2
    Tg(atoh7:GAL4,UAS:GAP-GFP) atoh7 GAL4GFP Danio rerio 1 3
    Tg(atoh7:GAL4-VP16) atoh7 GAL4VP16 Danio rerio 1 4
    Tg(atoh7:GAP-GFP) atoh7 GFP Danio rerio 1 17
    Tg(atoh7:GAP-RFP) atoh7 RFP Danio rerio 1 38
    Tg(atoh7:GCaMP) atoh7 GCaMP Danio rerio 1 3
    Tg(atoh7:GFP) atoh7 GFP Danio rerio 1 43
    tg(atoh7:qf2) atoh7 QF Danio rerio 1 1
    Tg(atoh7:rpl10a-GFP) atoh7 GFPrpl10a Danio rerio 1 1
    Tg2(atoh7:GAL4-VP16) atoh7 GAL4VP16 Danio rerio 1 2
    TgBAC(atoh7:Cre,myl7:Cerulean) atoh7myl7 CeruleanCre Danio rerio 1 1
    MARKER RELATIONSHIPS
    atoh7 Contained in: [BAC] DKEY-51A16 (1) (order this), RP71-PACKTRZ (1)
    atoh7 Encodes: [cDNA] MGC:86897 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131632 (1) 1031 nt
    Genomic GenBank:BX530079 (1) 166397 nt
    Select Tool
    Polypeptide UniProtKB:Q8AW52 (1) 134 aa
    Sequence Information (all 12)
    ORTHOLOGY for atoh7 ( Chr: 13 )
    CITATIONS (165)