ZFIN ID: ZDB-GENE-000920-1
Gene Name: endothelin 1
Gene Symbol: edn1    Nomenclature History

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Previous Names: et-1, et1, fb14d01, suc, sucker, wu:fb14d01 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 19 Mapping Details/Browsers
Description: Involved in several processes, including anterior lateral line neuromast development; face morphogenesis; and skeletal system development. Predicted to localize to the extracellular region. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); lung disease (multiple); obesity; obstructive sleep apnea; and rheumatoid arthritis. Is expressed in several structures, including cardiovascular system; ectoderm; mesoderm; neural crest; and pharyngeal arch. Orthologous to human EDN1 (endothelin 1).
Genome Resources: Alliance (1),  Gene:58032 (1),  Ensembl(GRCz11):ENSDARG00000036912 (2)
GENE EXPRESSION
All Expression Data: 51 figures from 32 publications
Directly Submitted Expression Data: 6 figures (12 images) from Thisse et al., 2005 [eu115]
Wild-type Stages, Structures: Gastrula:Bud (10.0h-10.33h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
tf216b Point Mutation Unknown Missense ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-edn1
    1
    MO1-edn1 N/A 15
    PHENOTYPE
    Data: 40 figures from 21 publications
    Observed in:
    DISEASE ASSOCIATED WITH edn1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Auriculocondylar syndrome 3 615706
    Question mark ears, isolated 612798
    {High density lipoprotein cholesterol level QTL 7}
    DISEASE ASSOCIATED WITH edn1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cartilage development (more)
    Cellular Component extracellular region (more)
    GO Terms (all 13)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Conserved_site IPR019764 Endothelin-like toxin, conserved site
    Domain IPR001928 Endothelin-like toxin
    Family IPR020475 Endothelin
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA edn1-201 (1)    Ensembl 1220
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM edn1
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(fabp10a:edn1,myl7:EGFP) fabp10amyl7 edn1EGFP Danio rerio 1 4
    Tg(hsp70l:GAL4,UAS:edn1) hsp70lUAS edn1GAL4 Danio rerio 1 2
    Tg(UAS:edn1,cryaa:Cerulean) cryaa Ceruleanedn1 Danio rerio 1 6
    MARKER RELATIONSHIPS
    edn1 Contained in: [BAC] DKEY-31K9 (1) (order this)
    edn1 Encodes: [EST] eu115 (1), fb14d01 (1)
    [cDNA] MGC:193745 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131519 (1) 1224 nt
    Genomic GenBank:CT573165 (1) 70864 nt
    Select Tool
    Polypeptide UniProtKB:A5WW41 (1) 188 aa
    Sequence Information (all 14)
    ORTHOLOGY for edn1 ( Chr: 19 )
    CITATIONS (95)