Gene

edn1

ID
ZDB-GENE-000920-1
Name
endothelin 1
Symbol
edn1 Nomenclature History
Previous Names
  • et-1
  • et1
  • fb14d01
  • suc
  • sucker
  • wu:fb14d01 (1)
Type
protein_coding_gene
Location
Chr: 19 Mapping Details/Browsers
Description
Involved in several processes, including anterior lateral line neuromast development; face morphogenesis; and skeletal system development. Predicted to localize to extracellular region. Is expressed in several structures, including cardiovascular system; ectoderm; mesoderm; neural crest; and pharyngeal arch. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); bronchial disease (multiple); obesity; obstructive sleep apnea; and rheumatoid arthritis. Orthologous to human EDN1 (endothelin 1).
Genome Resources
Note
None
Expression
All Expression Data
51 figures from 32 publications
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
40 figures from 21 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With edn1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Auriculocondylar syndrome 3 615706
Question mark ears, isolated 612798
{High density lipoprotein cholesterol level QTL 7}
Associated With edn1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR019764 Endothelin-like toxin, conserved site
Domain IPR001928 Endothelin-like toxin
Family IPR020475 Endothelin
Domain Details Per Protein
Protein Length Endothelin Endothelin-like toxin Endothelin-like toxin, conserved site
UniProtKB:A5WW41 188
UniProtKB:Q9I8G3 188
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations